Cecropia hololeuca: A new source of compounds with potential anti-inflammatory action

Our objective is to investigate the phytochemical components, antioxidant capacity and in vitro and in vivo anti-inflammatory action from Cecropia hololeuca bark aqueous extract (AECh). The chemical characterization of AECh was performed through CE-UV, FTIR and NMR Spectroscopy. In vitro assays were...

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Bibliographic Details
Published in:Natural product research 2021-08, Vol.35 (16), p.2772-2777
Main Authors: Machado, Emanuelle G., Cardoso, Oswaldo, Lima, Nerilson M., Carvalho, Paloma E., Barbosa, Alice D., Sobrinho, Guilherme F. S., Duarte, Jennifer F., Coelho, Laryssa R., Soares, Pietra P. C., Orneles, Ayane G., Santos, Ana Carolina B., Santos, Kamila B., Castro, Sandra B. R., de Oliveira, Marcone A. L., Carli, Alessandra P., Souza Alves, Caio Cesar
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-inflammatory agents
Antioxidants
Bark
Caffeic acid
Carrageenan
Catechin
Cecropia hololeuca
Cell viability
cytotoxicity
Edema
Flavonoids
Free radicals
Gallic acid
IL-1β
In vivo methods and tests
Inflammation
Macrophages
Magnetic resonance spectroscopy
NMR
NMR spectroscopy
Nuclear magnetic resonance
phenolic compounds
Plant extracts
Scavenging
Tumor necrosis factor-α
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Summary:Our objective is to investigate the phytochemical components, antioxidant capacity and in vitro and in vivo anti-inflammatory action from Cecropia hololeuca bark aqueous extract (AECh). The chemical characterization of AECh was performed through CE-UV, FTIR and NMR Spectroscopy. In vitro assays were performed with the AECh on murine macrophages J774A.1 cells in order to analyse cell viability, NO, TNF-α and IL-1β productions and the in vivo anti-inflammatory potential in acute carrageenan paw oedema in mice. The AECh showed a decrease in the production of NO, TNF-α and IL-1β, without altering the cell viability and reduction of the paw thickness in the 2nd, 3rd and 4th hour. The extract presented 72% free radical scavenging, 0.60% flavonoid content and showed the presence of gallic acid, caffeic acid and catechin as major constituents. The C. hololeuca bark extract showed important antioxidant and anti-inflammatory activity, emphasizing the industrial and pharmacological potential of this plant.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1663512