The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic...

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Bibliographic Details
Published in:Developmental cell 2019-09, Vol.50 (5), p.525-526
Main Authors: Himeda, Charis L., Jones, Peter L.
Format: Article
Language:English
Subjects:
Homeodomain Proteins
Humans
Immune Evasion
Muscular Dystrophy, Facioscapulohumeral
Neoplasms
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Summary:In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells. In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2019.08.010