Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant Coronary Artery Stenosis

Background:Monocytes in human peripheral blood are heterogeneous and can be divided into 2 groups, inflammatory and pro-inflammatory, according to the differential expression of CD14 and CD16. Pro-inflammatory monocytes (CD14+CD16+) seem to contribute to the development of coronary artery disease. T...

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Bibliographic Details
Published in:Circulation Journal 2019/10/25, Vol.83(11), pp.2250-2256
Main Authors: Kashiwagi, Manabu, Imanishi, Toshio, Ozaki, Yuichi, Taruya, Akira, Nishiguchi, Tsuyoshi, Katayama, Yosuke, Tanimoto, Takashi, Kuroi, Akio, Kubo, Takashi, Tanaka, Atsushi, Akasaka, Takashi
Format: Article
Language:English
Subjects:
Aged
Angina, Stable - blood
Angina, Stable - diagnostic imaging
Angina, Stable - immunology
Biomarkers - blood
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - immunology
Disease Progression
Female
GPI-Linked Proteins - blood
Humans
Inflammation - blood
Inflammation - diagnosis
Inflammation - immunology
Leukocyte Count
Lipopolysaccharide Receptors - blood
Male
Middle Aged
Monocyte subset
Monocytes - immunology
Phenotype
Predictive Value of Tests
Prognosis
Receptors, IgG - blood
Risk Factors
Time Factors
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Summary:Background:Monocytes in human peripheral blood are heterogeneous and can be divided into 2 groups, inflammatory and pro-inflammatory, according to the differential expression of CD14 and CD16. Pro-inflammatory monocytes (CD14+CD16+) seem to contribute to the development of coronary artery disease. This study aimed to investigate the involvement of specific human peripheral monocyte subsets in the development of future coronary events.Methods and Results:We enrolled 271 patients who were suspected to have either stable angina pectoris or silent myocardial ischemia and underwent coronary angiography (CAG). Two monocyte subsets (CD14+CD16−and CD14+CD16+) were measured by flow cytometry. Patients who did not undergo coronary artery revascularization at initial CAG were followed as the medical therapy group, which included 136 patients among whom 15 had future coronary events. The frequency of CD14+CD16+monocytes was significantly higher in patients who had future coronary events than in those who did not (P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-19-0520