Modulation of autophagy in traumatic brain injury

Traumatic brain injury (TBI) is defined as a traumatically induced structural injury or physiological disruption of brain function as a result of external forces, leading to adult disability and death. A growing body of evidence reveals that alterations in autophagy‐related proteins exist extensivel...

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Bibliographic Details
Published in:Journal of cellular physiology 2020-03, Vol.235 (3), p.1973-1985
Main Authors: Zeng, Zhiqing, Zhang, Yao, Jiang, Weiping, He, Lu, Qu, Hongtao
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
Autophagy
Autophagy - physiology
Brain
Brain - pathology
Brain Injuries, Traumatic - pathology
Disruption
Drug delivery
Head injuries
Humans
Inflammation
Inflammation - pathology
Inflammatory response
Oxidative stress
Oxidative Stress - physiology
Pathogenesis
Phagocytosis
Traumatic brain injury
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Summary:Traumatic brain injury (TBI) is defined as a traumatically induced structural injury or physiological disruption of brain function as a result of external forces, leading to adult disability and death. A growing body of evidence reveals that alterations in autophagy‐related proteins exist extensively in both experimentally and clinically after TBI. Of note, the autophagy pathway plays an essential role in pathophysiological processes, such as oxidative stress, inflammatory response, and apoptosis, thus contributing to neurological properties of TBI. With this in mind, this review summarizes a comprehensive overview on the beneficial and detrimental effects of autophagy in pathophysiological conditions and how these activities are linked to the pathogenesis of TBI. Moreover, the relationship between oxidative stress, inflammation, apoptosis, and autophagy occur TBI. Ultimately, multiple compounds and various drugs targeting the autophagy pathway are well described in TBI. Therefore, autophagy flux represents a potential clinical therapeutic value for the treatment of TBI and its complications. 1. Autophagy plays an essential role in pathophysiological processes, such as oxidative stress, inflammatory response, and apoptosis after traumatic brain injury (TBI), thus contributing to neuroprotective properties. 2. The relationship between oxidative stress, inflammation, apoptosis, and autophagy occur TB 3. Mltiple compounds and various drugs targeting the autophagy pathway are well described in TBI.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29173