Morphological Characteristics of Pericallosal Artery Aneurysms and Their High Propensity for Rupture

• Published in: World neurosurgery 2020-01, Vol.133, p.e320-e326
• Main Authors: Zhai, Xiao-Dong, Yu, Jia-Xing, Li, Chuan-Jie, Ren, Jian, Ji, Zhe, He, Chuan, Ye, Ming, Hu, Peng, Zhang, Hong-Qi
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Anatomical structure; Aneurysm, Ruptured - diagnostic imaging; Aneurysm, Ruptured - epidemiology; Aneurysm, Ruptured - pathology; Anterior Cerebral Artery - diagnostic imaging; Anterior Cerebral Artery - pathology; Aspect ratio; Cerebral Angiography - methods; Corpus Callosum - blood supply; Disease Susceptibility; Female; High risk of rupture; Humans; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - epidemiology; Intracranial Aneurysm - pathology; Male; Middle Aged; Morphological parameters; Pericallosal artery aneurysms; Retrospective Studies; Risk Factors; Size ratio; Young Adult
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2019.09.003

Compared with intracranial aneurysms (IAs) at other locations, pericallosal artery aneurysms (PAAs) have demonstrated an extremely high risk of rupture. However, owing to their rarity, our understanding of their morphological characteristics has been limited, and whether the morphological characteristics of PAAs contribute to this high rupture risk has remained unexplored. In the present study, we aimed to provide a detailed description of the morphological characteristics of PAAs and investigate the association between its morphology and rupture risk compared with anterior circulation IAs at other locations. A total of 40 patients with 45 PAAs and 348 patients with 392 anterior circulation IAs at other locations were recruited. The clinical and radiological data for these patients were retrospectively reviewed. The differences in the morphological parameters, including the aneurysm diameter, neck width, height, width, parent artery diameter, inflow angle, aspect ratio (AR), size ratio (SR), and aneurysm diameter/width ratio, between PAAs and other IA groups were compared. Of the 45 PAAs, 22 (48.9%) had ruptured. The proportion of ruptured aneurysms was greater for PAAs than for anterior circulation IAs at other locations. For both ruptured and unruptured anterior circulation IAs, PAAs had the highest AR and SR among all IA groups and had the largest inflow angle. The morphological characteristics of PAAs are unique. Compared with other anterior circulation IAs, PAAs have significantly increased ARs, SRs, and inflow angles, which, ultimately, promote their high propensity toward rupture.