Three new bioactive flavonoid glycosides from Viscum album

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4−10). Their structures were identified by analysis o...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2019-07, Vol.17 (7), p.545-550
Main Authors: DAI, Jia-Kun, CAO, Duo, LI, Cui-Hua, GAO, Jing, LI, Meng-Qing, FAN, Na, WEI, Ya-Hui, SUN, Zheng-Liang, HOU, Meng-Yang
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Cytotoxic activities
Flavonoid glycosides
Flavonoids - chemistry
Flavonoids - pharmacology
Glycosides - chemistry
Glycosides - pharmacology
Humans
Molecular Structure
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Viscum album
Viscum album - chemistry
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Summary:Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4−10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC50 ≤ 60.00 μmol·L−1), while the inhibition of TF-1 and Hela was not significant.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30076-7