Metabolomics analysis of seminal plasma in patients with idiopathic Oligoasthenoteratozoospermia using high‐resolution NMR spectroscopy

Background Male infertility is a global health issue caused by a combination of different factors. Specialists generally rely on semen analysis to diagnose male infertility. However, it is known that diagnostic semen analysis fails to identify about 50% of male infertility disorders. Recently, metab...

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Bibliographic Details
Published in:Andrology (Oxford) 2020-03, Vol.8 (2), p.450-456
Main Authors: Mumcu, A., Karaer, A., Dogan, B., Tuncay, G.
Format: Article
Language:English
Subjects:
Adult
Humans
Infertility
Magnetic Resonance Spectroscopy - methods
Male
Metabolites
metabolomics
Metabolomics - methods
NMR spectroscopy
oligoasthenoteratozoospermia
Oligospermia - diagnosis
Oligospermia - metabolism
Semen - metabolism
Semen Analysis - methods
seminal plasma
Spectrum analysis
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Summary:Background Male infertility is a global health issue caused by a combination of different factors. Specialists generally rely on semen analysis to diagnose male infertility. However, it is known that diagnostic semen analysis fails to identify about 50% of male infertility disorders. Recently, metabolomics has been proven to be a powerful technique for the diagnosis of different diseases. Objective To determine whether metabolites could be used as potential biomarkers for the diagnosis of male factor infertility through comparing seminal plasma samples from infertile men with oligoasthenoteratozospermia (OAT) and samples from normozoospermic controls. Materials and methods This study utilized high‐resolution 1H NMR spectroscopy to reveal whether the metabolomic changes of seminal plasma obtained from 31 patients with oligoasthenoteratozospermia (OAT) are different from the ones obtained from 28 normozoospermic controls. Results Multivariate statistical analysis of NMR data concluded that the metabolomic profile of samples from patients with OAT exhibits statistically significant differences when compared to the controls. The differences were based on the metabolites lactate, citrate, lysine, arginine, valine, glutamine, creatinine, α‐ketoglutaric acid, spermine, putrescine, and tyrosine. Except the tyrosine, levels of the above metabolites were significantly decreased in patients with OAT compared to the controls. The levels of citrate, choline, spermine, putrescine, α‐ketoglutaric acid, valine, and tyrosine were significantly different (p 
ISSN:2047-2919
2047-2927
DOI:10.1111/andr.12707