Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

• Published in: BioFactors (Oxford) 2019-11, Vol.45 (6), p.950-958
• Main Authors: Zhang, Haihua, Shi, Qiumei, Nan, Weixiao, Wang, Yaqi, Wang, Shiyong, Yang, Fuhe, Li, Guangyu
• Format: Article
• Language: English
• Subjects: Animals; beta Catenin - genetics; bilobalide; Cell Proliferation - drug effects; Cell Survival - drug effects; Cyclopentanes - chemistry; Cyclopentanes - pharmacology; dermal papilla; Dermis - drug effects; Dermis - growth & development; Furans - chemistry; Furans - pharmacology; Ginkgo biloba - chemistry; ginkgolide B; Ginkgolides - chemistry; Ginkgolides - pharmacology; hair follicle; Hair Follicle - drug effects; Hair Follicle - growth & development; Lactones - chemistry; Lactones - pharmacology; Mink - growth & development; Signal Transduction - drug effects; β‐catenin
• ISSN: 0951-6433; 1872-8081
• DOI: 10.1002/biof.1562

The regeneration of proliferation potential of dermal papilla (DP) cells contributes to the treatment of hair loss disorders. Ginkgolide B (GKB) and bilobalide (BB) are two functional components isolated from Ginkgo biloba that can promote hair growth. In the current study, the effect of GKB or BB on DP cell viability and the related signaling was assessed. Hair follicles were isolated from minks, and the growth of hair follicles was measured under the administration of GKB or BB. DP cells isolated from minks were also subjected to GKB or BB. The administration of GKB or BB induced the growth of hair follicles. The viability of DP cells was also increased by GKB or BB as illustrated by methyl thiazolyl tetrazolium and flow cytometry detection. Moreover, the secretion of VEGF was enhanced by GKB or BB. At molecular level, the activities of Akt, ERK1/2, and β‐catenin were induced by GKB, whereas BB only increased the activities of Akt and β‐catenin. In conclusion, although the two components influenced the β‐catenin signaling activity in distinct mechanisms, they both increased the viability of DP cells and promoted the cycle of hair follicles.