Evolving therapeutic goals in ulcerative colitis: towards disease clearance

In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse and hospitalization, pushing for histological remission to be embraced in clinical practice and clinical trials. Here, we propose the concept of disease clearance (symptomatic, endoscopic and histological remi...

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Bibliographic Details
Published in:Nature reviews. Gastroenterology & hepatology 2020-01, Vol.17 (1), p.1-2
Main Authors: Danese, Silvio, Roda, Giulia, Peyrin-Biroulet, Laurent
Format: Article
Language:English
Subjects:
692/4020/1503/1581/257
692/4020/1503/257/1389
692/700
Biomedicine
Biopsy
Care and treatment
Clinical trials
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - pathology
Colitis, Ulcerative - physiopathology
Colon
Colon - pathology
Colonoscopy
Comment
Endoscopy
Gastroenterology
Health aspects
Hepatology
Hospitalization
Humans
Inflammatory bowel disease
Intestinal Mucosa - pathology
Medicine
Medicine & Public Health
Monoclonal antibodies
Patient Care Planning
Patient Reported Outcome Measures
Recurrence
Remission
Remission Induction
Secondary Prevention
Tofacitinib
Ulcerative colitis
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Summary:In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse and hospitalization, pushing for histological remission to be embraced in clinical practice and clinical trials. Here, we propose the concept of disease clearance (symptomatic, endoscopic and histological remission) as the ultimate goal in the treatment of ulcerative colitis.
ISSN:1759-5045
1759-5053
DOI:10.1038/s41575-019-0211-1