Field-testing a single-dose immunocontraceptive in free-ranging male capybara (Hydrochoerus hydrochaeris): Evaluation of effects on reproductive physiology, secondary sexual characteristics, and agonistic behavior

• Published in: Animal reproduction science 2019-10, Vol.209, p.106148-106148, Article 106148
• Main Authors: Rosenfield, Derek A., Nichi, Marcilio, Losano, João D.A., Kawai, Giulia, Leite, Roberta F., Acosta, Alfredo J., Baquero, Oswaldo Santos, Pizzutto, Cristiane Schilbach
• Format: Article
• Language: English
• Subjects: Agonistic behavior; Agonistic Behavior - drug effects; Animals; Animals, Wild; Anti-fertility; Contraception, Immunologic - methods; Contraception, Immunologic - veterinary; Contraceptive Agents, Male - administration & dosage; Contraceptive Agents, Male - therapeutic use; Dose-Response Relationship, Drug; Female; GonaCon; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gonadotropin-Releasing Hormone - immunology; Immunocontraception; Male; Male capybara; Population control; Population Control - methods; Reproduction - drug effects; Rodentia - immunology; Rodentia - physiology; Semen Analysis - veterinary; Sexual Behavior, Animal - drug effects; Testis - drug effects; Vaccine Potency; Vaccines, Contraceptive - administration & dosage; Vaccines, Contraceptive - therapeutic use
• ISSN: 0378-4320; 1873-2232
• DOI: 10.1016/j.anireprosci.2019.106148

Controlling wildlife populations to mitigate human-wildlife conflicts and the spread of zoonotic diseases is an ever-growing necessity. The objective of this study was to evaluate a single-dose anti-gonadotropin-releasing hormone vaccine (GonaCon, USDA/NWRC, Fort Collins, CO, USA) as a non-lethal alternative for population control in free-ranging, synanthropic male capybara. In addition to infertility efficacy of this treatment, potential effects on the alpha male’s secondary sexual characteristics and agonist behavior need to be assessed because any alterations in these factors could lead to population management failure. The treatment group (n = 3) received 1 mL of the anti-GnRH vaccine, intramuscularly, and the control group (n = 2) a 1 mL sham vaccine. Reproductive behavior and social group dynamics were monitored for 30 days prior to inoculation (June 2017) with continuous observations occurring during the study period. Antifertility effects were assessed by conducting exams of testicular morphology, semen characteristics, and histological analysis (after 270 days via hemi-gonadectomy). Compared to the control group, the testicles of the treated males had severe atrophy (P