Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation

This study aimed to develop Eudragit® RL 100 nanocapsules loaded with desonide (DES) using açai oil (AO) or medium chain triglycerides (MCT) as oil core. Pre-formulation study showed that AO and MCT are suitable for nanocapsules preparation. The nanocapsules prepared with AO and MCT presented mean p...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2019-10, Vol.199, p.111606-111606, Article 111606
Main Authors: Rosa, Priscila, Friedrich, Mariane Lago, dos Santos, Juliana, Librelotto, Daniele Rubert Nogueira, Maurer, Luana Haselein, Emanuelli, Tatiana, da Silva, Cristiane de Bona, Adams, Andréa Inês Horn
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
açai oil
Cell Line
Cell Survival - drug effects
Desonide - chemistry
Desonide - pharmacology
Drug Compounding - methods
Drug Liberation
Drug Stability
Euterpe - chemistry
Evaluation
Fibroblasts
Free form
Humans
Irritant potential
Keratinocytes
Light
Mice
Nanocapsules - chemistry
Nanoparticles
Oil
Particle Size
Photodegradation
Photolysis
Photostability
Phototoxic activity
Phototoxicity
Plant Oils - chemistry
Plant Oils - pharmacology
Polydispersity
Polymethacrylic Acids - chemistry
Suspensions - chemistry
Therapeutic applications
Triglycerides
Triglycerides - chemistry
Viability
Zeta potential
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Description
Summary:This study aimed to develop Eudragit® RL 100 nanocapsules loaded with desonide (DES) using açai oil (AO) or medium chain triglycerides (MCT) as oil core. Pre-formulation study showed that AO and MCT are suitable for nanocapsules preparation. The nanocapsules prepared with AO and MCT presented mean particle size around 165 and 131 nm, respectively; polydispersity index values
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2019.111606