Immobilized Candida antarctica lipase B catalyzed synthesis of biodegradable polymers for biomedical applications

Enzymes, as green catalysts, can catalyze varied reactions with high efficiency. Among various types of enzymes, Candida antarctica lipase B (CALB) is the most commonly used one, due to its high catalytic activity in polymer synthesis. This review highlights the polymers synthesized via the catalysi...

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Bibliographic Details
Published in:Biomaterials science 2019-11, Vol.7 (12), p.4963-4983
Main Authors: Lu, Yao, Lv, Qijun, Liu, Bo, Liu, Jie
Format: Article
Language:English
Subjects:
Biocatalysis
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biodegradability
Biomedical materials
Catalysis
Catalysts
Catalytic activity
Chemical reactions
Chemical synthesis
Drug delivery systems
Enzymes
Enzymes, Immobilized - chemistry
Enzymes, Immobilized - metabolism
Fungal Proteins - chemistry
Fungal Proteins - metabolism
Lipase
Lipase - chemistry
Lipase - metabolism
Organic chemistry
Polyester resins
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Product safety
Ring opening polymerization
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Summary:Enzymes, as green catalysts, can catalyze varied reactions with high efficiency. Among various types of enzymes, Candida antarctica lipase B (CALB) is the most commonly used one, due to its high catalytic activity in polymer synthesis. This review highlights the polymers synthesized via the catalysis of immobilized CALB, and focuses on their applications in biomedical areas, especially their use in drug and gene delivery systems. Upholding the idea of sustainable and environment-friendly green chemistry, and emphasizing the safety of products applied for biomedical uses, lipase catalysts are better choices compared to inorganic metal catalysts. We introduced the background and advantages of lipase catalysis and reviewed the lipase-catalyzed synthetic routes involving ring opening polymerization, polycondensation and others. For biomedical applications, we mainly discuss enzymatically synthesized polyesters, due to their outstanding biodegradability and synthetic possibilities. We firstly introduced our early work as basic thinking, then we summarized the subsequent work that focused on developing multiple functional polyesters for different biomedical applications. Prominent experimental results have been shown and the significance of CALB-catalyzed synthesis has been proved.
ISSN:2047-4830
2047-4849
DOI:10.1039/c9bm00716d