Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea

Eleven new nitrogenous meroterpenoids, cinerols A–K (1–11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare 5H-pyrrolo­[1,2a]­benzimidazole moiety,...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-09, Vol.82 (9), p.2586-2593
Main Authors: Jiao, Wei-Hua, Li, Jing, Wang, Dan, Zhang, Meng-Meng, Liu, Li-Yun, Sun, Fan, Li, Jing-Ya, Capon, Robert J, Lin, Hou-Wen
Format: Article
Language:English
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Summary:Eleven new nitrogenous meroterpenoids, cinerols A–K (1–11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare 5H-pyrrolo­[1,2a]­benzimidazole moiety, while cinerols C–G (3–7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 μM; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein-tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8–27 μM.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00471