Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea

Eleven new nitrogenous meroterpenoids, cinerols A–K (1–11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare 5H-pyrrolo­[1,2a]­benzimidazole moiety,...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-09, Vol.82 (9), p.2586-2593
Main Authors: Jiao, Wei-Hua, Li, Jing, Wang, Dan, Zhang, Meng-Meng, Liu, Li-Yun, Sun, Fan, Li, Jing-Ya, Capon, Robert J, Lin, Hou-Wen
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cited_by cdi_FETCH-LOGICAL-a348t-750756c84cc53ea2eaa933667f8a38350f5888b07d86a4d5a12ae7779900a6ce3
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container_end_page 2593
container_issue 9
container_start_page 2586
container_title Journal of natural products (Washington, D.C.)
container_volume 82
creator Jiao, Wei-Hua
Li, Jing
Wang, Dan
Zhang, Meng-Meng
Liu, Li-Yun
Sun, Fan
Li, Jing-Ya
Capon, Robert J
Lin, Hou-Wen
description Eleven new nitrogenous meroterpenoids, cinerols A–K (1–11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare 5H-pyrrolo­[1,2a]­benzimidazole moiety, while cinerols C–G (3–7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 μM; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein-tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8–27 μM.
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title Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
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