Early versus delayed extubation in extremely preterm neonates: a retrospective cohort study

Objective To evaluate clinical outcomes associated with extubation timing among extremely preterm neonates. Design/Methods Neonates 24 h; control group) after meeting extubation criteria. Patients with known severe IVH and/or significant PDA prior to meeting extubation criteria were excluded. Result...

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Bibliographic Details
Published in:Journal of perinatology 2020-01, Vol.40 (1), p.118-123
Main Authors: Mukerji, Amit, Razak, Abdul, Aggarwal, Akanksha, Jacobi, Eyal, Musa, May, Alwahab, Zeina, Baier, John, Narvey, Michael, Shah, Prakesh S.
Format: Article
Language:English
Subjects:
692/308/174
692/700/1720
Age
Analysis
Clinical outcomes
Cohort analysis
Criteria
Drug dosages
Extubation
Infants
Infants (Premature)
Intubation
Medicine
Medicine & Public Health
Neonates
Newborn babies
Patients
Pediatric Surgery
Pediatrics
Premature birth
Respiratory therapy
Studies
Surfactants
Survival
Ventilators
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Summary:Objective To evaluate clinical outcomes associated with extubation timing among extremely preterm neonates. Design/Methods Neonates 24 h; control group) after meeting extubation criteria. Patients with known severe IVH and/or significant PDA prior to meeting extubation criteria were excluded. Results Of 197 included infants, 75 were in exposure group. Survival without BPD (aOR 1.26; 95% CI 0.62–2.56; P  = 0.52) and survival without severe IVH (aOR 1.98; 95% CI 0.93–4.23; P  = 0.08) were not different, adjusted for GA, SNAP, number of surfactant doses and center. Conclusions Extubation within 24 h of meeting extubation criteria in neonates
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-019-0495-6