Levcromakalim, an Adenosine Triphosphate‐Sensitive Potassium Channel Opener, Dilates Extracerebral but not Cerebral Arteries

Background ATP‐sensitive potassium (KATP) channel opener levcromakalim induces migraine attacks in migraine patients. Underlying mechanisms responsible for headache and migraine induction after levcromakalim infusion are unknown. Objective To investigate the effect of levcromakalim on the cranial ar...

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Bibliographic Details
Published in:Headache 2019-10, Vol.59 (9), p.1468-1480
Main Authors: Al‐Karagholi, Mohammad Al‐Mahdi, Ghanizada, Hashmat, Hansen, Jakob M., Skovgaard, Lene T., Olesen, Jes, Larsson, Henrik B. W., Amin, Faisal M., Ashina, Messoud
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Arteries
ATP
BRL 34915
BRL 38227
Circumferences
Dilation
Headache
Headaches
healthy volunteers
levcromakalim
middle meningeal artery
Migraine
Nociceptors
Pain perception
Potassium
potassium channel openers
Sumatriptan
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Summary:Background ATP‐sensitive potassium (KATP) channel opener levcromakalim induces migraine attacks in migraine patients. Underlying mechanisms responsible for headache and migraine induction after levcromakalim infusion are unknown. Objective To investigate the effect of levcromakalim on the cranial arteries and to explore the possible relationship between the middle meningeal artery (MMA) dilation and headache. Methods In a double‐blind, randomized, placebo‐controlled study, 20 healthy volunteers were scanned at the baseline and repeatedly after infusion of levcromakalim (n = 14) and placebo (n = 6). All participants received a subcutaneous injection of sumatriptan 6 mg before the last scanning. Results The MMA circumference was significantly larger after levcromakalim compared with placebo (P 
ISSN:0017-8748
1526-4610
DOI:10.1111/head.13634