Loading…
Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats
Background and objectives Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date,...
Saved in:
| Published in: | Journal of periodontal research 2020-01, Vol.55 (1), p.141-151 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3 |
| container_end_page | 151 |
| container_issue | 1 |
| container_start_page | 141 |
| container_title | Journal of periodontal research |
| container_volume | 55 |
| creator | Marins, Letícia Macedo Napimoga, Marcelo Henrique Malta, Fernando de Souza Miranda, Tamires Szeremeske Nani, Edson Parra Franco, Beatriz da Silva Tavares Silva, Hélio Doyle Pereira Duarte, Poliana Mendes |
| description | Background and objectives
Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats.
Methods
Ninety‐six rats were assigned to one of the following groups: sham‐surgery + water (estrogen‐sufficient; n = 24); ovariectomy + water (estrogen‐deficient; n = 24), sham‐surgery + strontium ranelate (ranelate/estrogen‐sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen‐deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end of the experiment. On the 21st day after ovariectomy, one first mandibular molar received a ligature, while the contralateral tooth was left unligated. Eight rats per group were killed at 10, 20, and 30 days after ligature placement. Bone loss (BL) and trabecular bone area (TBA) were analyzed in the furcation area of ligated and unligated teeth at all experimental times by histometry. Tartrate‐resistant acid phosphatase (TRAP) positive cells and immunohistochemical staining for osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), and receptor activator of NF‐КB ligand (RANKL) were assessed in the ligated teeth at 30 days after ligature placement.
Results
At 10 and 30 days, ligated teeth of the estrogen‐deficient group exhibited higher BL, when compared to all other groups (P |
| doi_str_mv | 10.1111/jre.12697 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2295475195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2295475195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3</originalsourceid><addsrcrecordid>eNp1kc1KJDEUhYOMaOvMwhcYArPRRbX5qUoqy6Fp_2gQZGYdUqkbSVOd6kmqmOmdj-Az-iSmbRUR5m7C5Xw5nOQgdELJlOY5X0aYUiaU3EMTKggpiBTVFzQhhLGCl3V5iI5SWpK8C6kO0CGnFVdU1hP0b-4c2CHh3uE0xD4MflzhaAJ0ZgDcB9z5ezOMEZ4eHn1oRwstXkP0fbtlB5-wDxi2V-8hZKYF562HMGAT2o9CGt2bEs2QvqJ9Z7oE317PY_T7Yv5rdlUsbi-vZz8XheUVlwUXtZSC1aUj1jjRGGJLyayqa-IkF6ZsaFlXjjWsqZVyrSs5WGaBWICGupYfo9Od7zr2f8acR698stB1-Yn9mDRjqiplRVWV0R-f0GU_xpDTaZbDKKKoUJk621E29ilFcHod_crEjaZEb-vQuQ79Ukdmv786js0K2nfy7f8zcL4D_voONv930jd3853lMy0lmaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2353909169</pqid></control><display><type>article</type><title>Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats</title><source>Wiley</source><creator>Marins, Letícia Macedo ; Napimoga, Marcelo Henrique ; Malta, Fernando de Souza ; Miranda, Tamires Szeremeske ; Nani, Edson Parra ; Franco, Beatriz da Silva Tavares ; Silva, Hélio Doyle Pereira ; Duarte, Poliana Mendes</creator><creatorcontrib>Marins, Letícia Macedo ; Napimoga, Marcelo Henrique ; Malta, Fernando de Souza ; Miranda, Tamires Szeremeske ; Nani, Edson Parra ; Franco, Beatriz da Silva Tavares ; Silva, Hélio Doyle Pereira ; Duarte, Poliana Mendes</creatorcontrib><description><![CDATA[Background and objectives
Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats.
Methods
Ninety‐six rats were assigned to one of the following groups: sham‐surgery + water (estrogen‐sufficient; n = 24); ovariectomy + water (estrogen‐deficient; n = 24), sham‐surgery + strontium ranelate (ranelate/estrogen‐sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen‐deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end of the experiment. On the 21st day after ovariectomy, one first mandibular molar received a ligature, while the contralateral tooth was left unligated. Eight rats per group were killed at 10, 20, and 30 days after ligature placement. Bone loss (BL) and trabecular bone area (TBA) were analyzed in the furcation area of ligated and unligated teeth at all experimental times by histometry. Tartrate‐resistant acid phosphatase (TRAP) positive cells and immunohistochemical staining for osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), and receptor activator of NF‐КB ligand (RANKL) were assessed in the ligated teeth at 30 days after ligature placement.
Results
At 10 and 30 days, ligated teeth of the estrogen‐deficient group exhibited higher BL, when compared to all other groups (P < .05). At 10 days, TBAs were higher in the unligated teeth of strontium ranelate‐treated groups, when compared to those of untreated groups (P < .05). At 30 days, the ligated teeth of the estrogen‐deficient group exhibited lower TBA than the other groups (P < .05). There were no differences among groups regarding the number of TRAP‐stained cells (P < .05). The strontium ranelate‐treated groups exhibited lower expressions of OCN and RANKL than the untreated groups (P < .05). The estrogen‐sufficient group presented higher staining for OPG than both treated and untreated estrogen‐deficient groups (P < .05).
Conclusions
Strontium ranelate prevented ligature‐induced BL in an estrogen‐deficiency condition and, to a certain extent, increased TBA in the presence and absence of periodontal collapse in states of estrogen deficiency and estrogen sufficiency. Furthermore, strontium ranelate also affected the expression of bone markers, appearing to have acted predominantly as an anti‐resorptive agent.]]></description><identifier>ISSN: 0022-3484</identifier><identifier>EISSN: 1600-0765</identifier><identifier>DOI: 10.1111/jre.12697</identifier><identifier>PMID: 31539178</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Acid phosphatase (tartrate-resistant) ; Alveolar bone ; alveolar bone loss ; Alveolar Bone Loss - drug therapy ; Animals ; Biological activity ; Bone loss ; Cancellous bone ; Dentistry ; Estrogens - deficiency ; Gum disease ; Hormone replacement therapy ; Mandible ; Osteocalcin ; Osteocalcin - metabolism ; Osteopontin ; Osteopontin - metabolism ; Osteoporosis ; Osteoprotegerin ; Osteoprotegerin - metabolism ; Ovariectomy ; Periodontitis ; Periodontitis - drug therapy ; RANK ligand ; RANK Ligand - metabolism ; Rats ; Rats, Wistar ; Strontium ; strontium ranelate ; Surgery ; Teeth ; Thiophenes - pharmacology ; TRANCE protein</subject><ispartof>Journal of periodontal research, 2020-01, Vol.55 (1), p.141-151</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3</citedby><cites>FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3</cites><orcidid>0000-0001-8872-5943</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31539178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marins, Letícia Macedo</creatorcontrib><creatorcontrib>Napimoga, Marcelo Henrique</creatorcontrib><creatorcontrib>Malta, Fernando de Souza</creatorcontrib><creatorcontrib>Miranda, Tamires Szeremeske</creatorcontrib><creatorcontrib>Nani, Edson Parra</creatorcontrib><creatorcontrib>Franco, Beatriz da Silva Tavares</creatorcontrib><creatorcontrib>Silva, Hélio Doyle Pereira</creatorcontrib><creatorcontrib>Duarte, Poliana Mendes</creatorcontrib><title>Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats</title><title>Journal of periodontal research</title><addtitle>J Periodontal Res</addtitle><description><![CDATA[Background and objectives
Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats.
Methods
Ninety‐six rats were assigned to one of the following groups: sham‐surgery + water (estrogen‐sufficient; n = 24); ovariectomy + water (estrogen‐deficient; n = 24), sham‐surgery + strontium ranelate (ranelate/estrogen‐sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen‐deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end of the experiment. On the 21st day after ovariectomy, one first mandibular molar received a ligature, while the contralateral tooth was left unligated. Eight rats per group were killed at 10, 20, and 30 days after ligature placement. Bone loss (BL) and trabecular bone area (TBA) were analyzed in the furcation area of ligated and unligated teeth at all experimental times by histometry. Tartrate‐resistant acid phosphatase (TRAP) positive cells and immunohistochemical staining for osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), and receptor activator of NF‐КB ligand (RANKL) were assessed in the ligated teeth at 30 days after ligature placement.
Results
At 10 and 30 days, ligated teeth of the estrogen‐deficient group exhibited higher BL, when compared to all other groups (P < .05). At 10 days, TBAs were higher in the unligated teeth of strontium ranelate‐treated groups, when compared to those of untreated groups (P < .05). At 30 days, the ligated teeth of the estrogen‐deficient group exhibited lower TBA than the other groups (P < .05). There were no differences among groups regarding the number of TRAP‐stained cells (P < .05). The strontium ranelate‐treated groups exhibited lower expressions of OCN and RANKL than the untreated groups (P < .05). The estrogen‐sufficient group presented higher staining for OPG than both treated and untreated estrogen‐deficient groups (P < .05).
Conclusions
Strontium ranelate prevented ligature‐induced BL in an estrogen‐deficiency condition and, to a certain extent, increased TBA in the presence and absence of periodontal collapse in states of estrogen deficiency and estrogen sufficiency. Furthermore, strontium ranelate also affected the expression of bone markers, appearing to have acted predominantly as an anti‐resorptive agent.]]></description><subject>Acid phosphatase (tartrate-resistant)</subject><subject>Alveolar bone</subject><subject>alveolar bone loss</subject><subject>Alveolar Bone Loss - drug therapy</subject><subject>Animals</subject><subject>Biological activity</subject><subject>Bone loss</subject><subject>Cancellous bone</subject><subject>Dentistry</subject><subject>Estrogens - deficiency</subject><subject>Gum disease</subject><subject>Hormone replacement therapy</subject><subject>Mandible</subject><subject>Osteocalcin</subject><subject>Osteocalcin - metabolism</subject><subject>Osteopontin</subject><subject>Osteopontin - metabolism</subject><subject>Osteoporosis</subject><subject>Osteoprotegerin</subject><subject>Osteoprotegerin - metabolism</subject><subject>Ovariectomy</subject><subject>Periodontitis</subject><subject>Periodontitis - drug therapy</subject><subject>RANK ligand</subject><subject>RANK Ligand - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Strontium</subject><subject>strontium ranelate</subject><subject>Surgery</subject><subject>Teeth</subject><subject>Thiophenes - pharmacology</subject><subject>TRANCE protein</subject><issn>0022-3484</issn><issn>1600-0765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1KJDEUhYOMaOvMwhcYArPRRbX5qUoqy6Fp_2gQZGYdUqkbSVOd6kmqmOmdj-Az-iSmbRUR5m7C5Xw5nOQgdELJlOY5X0aYUiaU3EMTKggpiBTVFzQhhLGCl3V5iI5SWpK8C6kO0CGnFVdU1hP0b-4c2CHh3uE0xD4MflzhaAJ0ZgDcB9z5ezOMEZ4eHn1oRwstXkP0fbtlB5-wDxi2V-8hZKYF562HMGAT2o9CGt2bEs2QvqJ9Z7oE317PY_T7Yv5rdlUsbi-vZz8XheUVlwUXtZSC1aUj1jjRGGJLyayqa-IkF6ZsaFlXjjWsqZVyrSs5WGaBWICGupYfo9Od7zr2f8acR698stB1-Yn9mDRjqiplRVWV0R-f0GU_xpDTaZbDKKKoUJk621E29ilFcHod_crEjaZEb-vQuQ79Ukdmv786js0K2nfy7f8zcL4D_voONv930jd3853lMy0lmaA</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Marins, Letícia Macedo</creator><creator>Napimoga, Marcelo Henrique</creator><creator>Malta, Fernando de Souza</creator><creator>Miranda, Tamires Szeremeske</creator><creator>Nani, Edson Parra</creator><creator>Franco, Beatriz da Silva Tavares</creator><creator>Silva, Hélio Doyle Pereira</creator><creator>Duarte, Poliana Mendes</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8872-5943</orcidid></search><sort><creationdate>202001</creationdate><title>Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats</title><author>Marins, Letícia Macedo ; Napimoga, Marcelo Henrique ; Malta, Fernando de Souza ; Miranda, Tamires Szeremeske ; Nani, Edson Parra ; Franco, Beatriz da Silva Tavares ; Silva, Hélio Doyle Pereira ; Duarte, Poliana Mendes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acid phosphatase (tartrate-resistant)</topic><topic>Alveolar bone</topic><topic>alveolar bone loss</topic><topic>Alveolar Bone Loss - drug therapy</topic><topic>Animals</topic><topic>Biological activity</topic><topic>Bone loss</topic><topic>Cancellous bone</topic><topic>Dentistry</topic><topic>Estrogens - deficiency</topic><topic>Gum disease</topic><topic>Hormone replacement therapy</topic><topic>Mandible</topic><topic>Osteocalcin</topic><topic>Osteocalcin - metabolism</topic><topic>Osteopontin</topic><topic>Osteopontin - metabolism</topic><topic>Osteoporosis</topic><topic>Osteoprotegerin</topic><topic>Osteoprotegerin - metabolism</topic><topic>Ovariectomy</topic><topic>Periodontitis</topic><topic>Periodontitis - drug therapy</topic><topic>RANK ligand</topic><topic>RANK Ligand - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Strontium</topic><topic>strontium ranelate</topic><topic>Surgery</topic><topic>Teeth</topic><topic>Thiophenes - pharmacology</topic><topic>TRANCE protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marins, Letícia Macedo</creatorcontrib><creatorcontrib>Napimoga, Marcelo Henrique</creatorcontrib><creatorcontrib>Malta, Fernando de Souza</creatorcontrib><creatorcontrib>Miranda, Tamires Szeremeske</creatorcontrib><creatorcontrib>Nani, Edson Parra</creatorcontrib><creatorcontrib>Franco, Beatriz da Silva Tavares</creatorcontrib><creatorcontrib>Silva, Hélio Doyle Pereira</creatorcontrib><creatorcontrib>Duarte, Poliana Mendes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marins, Letícia Macedo</au><au>Napimoga, Marcelo Henrique</au><au>Malta, Fernando de Souza</au><au>Miranda, Tamires Szeremeske</au><au>Nani, Edson Parra</au><au>Franco, Beatriz da Silva Tavares</au><au>Silva, Hélio Doyle Pereira</au><au>Duarte, Poliana Mendes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats</atitle><jtitle>Journal of periodontal research</jtitle><addtitle>J Periodontal Res</addtitle><date>2020-01</date><risdate>2020</risdate><volume>55</volume><issue>1</issue><spage>141</spage><epage>151</epage><pages>141-151</pages><issn>0022-3484</issn><eissn>1600-0765</eissn><abstract><![CDATA[Background and objectives
Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti‐resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats.
Methods
Ninety‐six rats were assigned to one of the following groups: sham‐surgery + water (estrogen‐sufficient; n = 24); ovariectomy + water (estrogen‐deficient; n = 24), sham‐surgery + strontium ranelate (ranelate/estrogen‐sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen‐deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end of the experiment. On the 21st day after ovariectomy, one first mandibular molar received a ligature, while the contralateral tooth was left unligated. Eight rats per group were killed at 10, 20, and 30 days after ligature placement. Bone loss (BL) and trabecular bone area (TBA) were analyzed in the furcation area of ligated and unligated teeth at all experimental times by histometry. Tartrate‐resistant acid phosphatase (TRAP) positive cells and immunohistochemical staining for osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), and receptor activator of NF‐КB ligand (RANKL) were assessed in the ligated teeth at 30 days after ligature placement.
Results
At 10 and 30 days, ligated teeth of the estrogen‐deficient group exhibited higher BL, when compared to all other groups (P < .05). At 10 days, TBAs were higher in the unligated teeth of strontium ranelate‐treated groups, when compared to those of untreated groups (P < .05). At 30 days, the ligated teeth of the estrogen‐deficient group exhibited lower TBA than the other groups (P < .05). There were no differences among groups regarding the number of TRAP‐stained cells (P < .05). The strontium ranelate‐treated groups exhibited lower expressions of OCN and RANKL than the untreated groups (P < .05). The estrogen‐sufficient group presented higher staining for OPG than both treated and untreated estrogen‐deficient groups (P < .05).
Conclusions
Strontium ranelate prevented ligature‐induced BL in an estrogen‐deficiency condition and, to a certain extent, increased TBA in the presence and absence of periodontal collapse in states of estrogen deficiency and estrogen sufficiency. Furthermore, strontium ranelate also affected the expression of bone markers, appearing to have acted predominantly as an anti‐resorptive agent.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31539178</pmid><doi>10.1111/jre.12697</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8872-5943</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3484 |
| ispartof | Journal of periodontal research, 2020-01, Vol.55 (1), p.141-151 |
| issn | 0022-3484 1600-0765 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2295475195 |
| source | Wiley |
| subjects | Acid phosphatase (tartrate-resistant) Alveolar bone alveolar bone loss Alveolar Bone Loss - drug therapy Animals Biological activity Bone loss Cancellous bone Dentistry Estrogens - deficiency Gum disease Hormone replacement therapy Mandible Osteocalcin Osteocalcin - metabolism Osteopontin Osteopontin - metabolism Osteoporosis Osteoprotegerin Osteoprotegerin - metabolism Ovariectomy Periodontitis Periodontitis - drug therapy RANK ligand RANK Ligand - metabolism Rats Rats, Wistar Strontium strontium ranelate Surgery Teeth Thiophenes - pharmacology TRANCE protein |
| title | Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A40%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20strontium%20ranelate%20on%20ligature%E2%80%90induced%20periodontitis%20in%20estrogen%E2%80%90deficient%20and%20estrogen%E2%80%90sufficient%20rats&rft.jtitle=Journal%20of%20periodontal%20research&rft.au=Marins,%20Let%C3%ADcia%20Macedo&rft.date=2020-01&rft.volume=55&rft.issue=1&rft.spage=141&rft.epage=151&rft.pages=141-151&rft.issn=0022-3484&rft.eissn=1600-0765&rft_id=info:doi/10.1111/jre.12697&rft_dat=%3Cproquest_cross%3E2295475195%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3537-368776284f0caf6ba0c472c9880f736a4b1485f2b2b899fdf43ec2ce0ceeb1fd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2353909169&rft_id=info:pmid/31539178&rfr_iscdi=true |