Test-Retest Reproducibility of Response Duration in Tinnitus Patients with Positive Residual Inhibition

Purpose: Functional imaging is often used to try to elucidate the pathophysiological mechanism of tinnitus. Residual inhibition, the temporary suppression of tinnitus after application of a masking noise, could be an interesting technique to modulate tinnitus perception in functional imaging paradig...

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Bibliographic Details
Published in:Journal of speech, language, and hearing research language, and hearing research, 2019-09, Vol.62 (9), p.3531-3544
Main Authors: Deklerck, Ann N, Degeest, Sofie, Dhooge, Ingeborg J. M, Keppler, Hannah
Format: Article
Language:English
Subjects:
Audiology
Brain research
Clinical medicine
Cognitive Restructuring
Counseling Techniques
Data Collection
Diagnostic Tests
Error of Measurement
Etiology
Hearing disorders
Hearing Impairments
Informed Consent
Inhibition
Masking
Neurosciences
Noise
Otolaryngology
Pathology
Patients
Physiology
Psychoacoustics
Questionnaires
Reproducibility
Responses
Tinnitus
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Summary:Purpose: Functional imaging is often used to try to elucidate the pathophysiological mechanism of tinnitus. Residual inhibition, the temporary suppression of tinnitus after application of a masking noise, could be an interesting technique to modulate tinnitus perception in functional imaging paradigms. The purposes of this study were to primarily assess reproducibility of the (partial) positive residual inhibition response duration in patients with tinnitus and to explore its utility in experimental designs. Method: Patients with tinnitus exhibiting a (partial) positive residual inhibition response or tinnitus reduction after a 1-min white noise presentation were selected from a broad consulting tinnitus population. In 27 patients, this response was tested 4 times: twice during initial testing and twice during a retest of the psychoacoustic tinnitus measures, 4-8 weeks after initial consultation. In 17 patients with stable residual inhibition responses, reproducibility of response duration, the duration of tinnitus reduction up to pretesting state, was analyzed. Results: Initial testing showed a residual inhibition duration of 29.5 s on average. Test-retest reproducibility of response duration was shown to be reliable with an ICC(3, 4) of 0.871 (95% CI [0.733, 0.948]) and a standard error of measurement of 6.64 s. Conclusions: This study indicates the good test-retest reproducibility of residual inhibition duration in our subset of 17 patients with stable (partial) positive residual inhibition. Residual inhibition is, therefore, a technique that can potentially be used for temporary tinnitus manipulation in experimental paradigms to unravel tinnitus pathophysiology.
ISSN:1092-4388
1558-9102
DOI:10.1044/2019_JSLHR-H-18-0514