Patients with musculoskeletal dysplasia undergoing total joint arthroplasty are at increased risk of surgical site Infection

Musculoskeletal dysplasias (MSD) are inherited conditions of abnormal cartilage and bone development and remodeling which include, amongst others, multiple epiphyseal dysplasia (MED), spondyloepiphyseal dysplasia (SED), achondroplasia, and hypochondroplasia. The aim of this study was to compare pati...

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Bibliographic Details
Published in:Orthopaedics & traumatology, surgery & research surgery & research, 2019-11, Vol.105 (7), p.1297-1301
Main Authors: Patel, Harshadkumar, Cichos, Kyle H., Moon, Andrew S., McGwin, Gerald, Ponce, Brent A., Ghanem, Elie S.
Format: Article
Language:English
Subjects:
Adult
Aged
Arthroplasty, Replacement, Hip - adverse effects
Arthroplasty, Replacement, Knee - adverse effects
Cohort Studies
Comorbidity
Dysplasia
Female
Humans
Joint Instability
Male
Middle Aged
Musculoskeletal Diseases
Musculoskeletal dysplasia
Osteochondrodysplasias
Outcomes
Perioperative
Retrospective Studies
Risk Factors
Surgical Wound Infection - etiology
Total joint arthroplasty
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Summary:Musculoskeletal dysplasias (MSD) are inherited conditions of abnormal cartilage and bone development and remodeling which include, amongst others, multiple epiphyseal dysplasia (MED), spondyloepiphyseal dysplasia (SED), achondroplasia, and hypochondroplasia. The aim of this study was to compare patient characteristics and in-hospital complications between MSD and non-MSD patients undergoing total joint arthroplasty (TJA). MSD patients undergoing TJA are at increased risk of in-hospital post-operative complications and mortality compared to non-MSD patients. The Nationwide Inpatient Sample (NIS) from the years 2005 to 2014 was used for this retrospective cohort study. International Classification of Diseases, Clinical Modifications (ICD-9-CM) procedure codes identified primary total knee arthroplasty (TKA) and total hip arthroplasty (THA) procedures and were used to separate MSD and non-MSD patients. Patients with trauma or malignancy as primary diagnoses, non-elective procedures, revision procedures, and concurrent bilateral surgeries were excluded. Patients were compared using linear regression or multivariate logistic regression analysis to control for confounders. All statistical analyses were performed taking into account the NIS sampling scheme and associated sampling weights. A total of 1,255 patients comprised the MSD group and 8,027,181 patients the non-MSD group. MSD patients were younger than non-MSD patients (50.9 vs. 65.8 years, p
ISSN:1877-0568
1877-0568
DOI:10.1016/j.otsr.2019.06.013