Esophagectomy for the patients with squamous cell carcinoma of the esophagus after allogeneic hematopoietic stem cell transplantation

• Published in: International journal of clinical oncology 2020, Vol.25 (1), p.82-88
• Main Authors: Kato, Fumihiko, Daiko, Hiroyuki, Kanamori, Jun, Inamoto, Yoshihiro, Fukuda, Takahiro, Hayashi, Koji, Tachimori, Yuji, Koyanagi, Kazuo
• Format: Article
• Language: English
• Subjects: Adult; Antibiotics; Cancer Research; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - etiology; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma - etiology; Esophageal Squamous Cell Carcinoma - pathology; Esophageal Squamous Cell Carcinoma - surgery; Esophagectomy - adverse effects; Esophagectomy - mortality; Esophagus; Female; Gastrointestinal surgery; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; Humans; Intubation; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Neoplasms, Second Primary - etiology; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - surgery; Oncology; Original Article; Patients; Pneumonia; Postoperative Complications - prevention & control; Prognosis; Respiratory failure; Retrospective Studies; Squamous cell carcinoma; Stem cell transplantation; Stem cells; Surgery; Surgical Oncology; Surgical outcomes; Treatment Outcome
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-019-01549-0

Background The number of long-term survivors after allogeneic hematopoietic stem cell transplantation (HSCT) has increased recently. Esophageal squamous cell carcinoma occurs at a particularly high incidence as a secondary cancer after HSCT. However, standard treatment for these patients has not been established yet. The objectives of this study were to investigate outcomes of esophagectomy for esophageal carcinoma developed in HSCT patients, and to provide the appropriate perioperative management. Methods Ten HSCT patients underwent esophagectomy for esophageal squamous cell carcinoma between December 2007 and September 2017 at the National Cancer Center Hospital. The surgical outcomes and long-term prognosis of these patients were reviewed retrospectively. Results In the former group, 5 of the 7 patients (71.4%) developed pneumonia after esophagectomy, with two of them requiring intubation because of respiratory failure. None of the three patients of the latter group, who received broad-spectrum antibiotics for more than 7 days after the surgery, developed any postoperative complications. The estimated survival probability of these patients at 5 years after the surgery was 53.3%. Conclusions HSCT patients have an extremely high risk of developing pneumonia after esophagectomy, and the condition can easily become serious. Therefore, broad-spectrum antibiotics should be administered prophylactically to prevent severe pneumonia during the perioperative period in these patients.