Risk factors of post-surgery complications in children with thyroid cancer

• Published in: International journal of pediatric otorhinolaryngology 2019-12, Vol.127, p.109673-109673, Article 109673
• Main Authors: Babala, Jozef, Zahradníková, Petra, Béder, Igor, Fedorová, Lenka, Lindák, Martin, Košťálová, Ľudmila, Pribilincová, Zuzana, Staník, Juraj, Králik, Róbert
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Follicular - surgery; Adolescent; Carcinoma, Neuroendocrine - surgery; Carcinoma, Papillary - surgery; Child; Female; Humans; Hypoparathyroidism - etiology; Lymphatic Metastasis; Male; Multiple Endocrine Neoplasia - surgery; Neck; Neck Dissection - adverse effects; Postoperative Complications - etiology; Retrospective Studies; Risk Factors; Thyroid cancer; Thyroid Neoplasms - pathology; Thyroid Neoplasms - surgery; Thyroid surgery; Thyroidectomy; Thyroidectomy - adverse effects; Thyroidectomy - methods; Vocal Cord Paralysis - etiology
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2019.109673

Thyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. The frequency, 2. Etiology, and 3. Risk factors of post-surgery complications of thyroid cancer. A retrospective analysis including risk factors for post-surgery complications of patients treated for thyroid malignancies in years 2006–2018 was performed. Over a period of 12 years 22 patients with thyroid malignancy (68% female; 12.6 ± 4.0 years of age, median follow-up 6 years) were identified. Histologically, 12 (55%) patients had papillary carcinoma. Six patients (27.3%) had multiple endocrine neoplasia type 2 (MEN2) syndrome, 3 (13.7%) patients had medullary carcinoma and 1 patient had follicular carcinoma. Neck lymph node metastases were diagnosed in 8 (36.4%), distant metastases in 6 (27.3%), and both locations were involved in 4 (18.2%) patients. Six (27.3%) children had surgical complications: 1 child had unilateral vocal cord paralysis and transient hypoparathyroidism and 5 had transient hypoparathyroidism. The higher risk of surgery complications in forward stepwise logistic regression was associated in with distant metastases (R2 = 0.584, OR 52.63, p = 0.010). Postoperative complications were significantly associated with presence of distant metastases. Favorable results were observed in with children with MEN2 syndrome.