Diverse histomorphology of HER2‐positive breast carcinomas based on differential ER expression

Aims HER2‐positive (HER2+) breast carcinoma (BC) cases are often treated similarly; however, they can be classified as either luminal B (LH) or non‐luminal type (NLH) BC, which have different prognoses. In this study, we investigated the clinicohistomorphological features of each HER2+ BC subgroup....

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Bibliographic Details
Published in:Histopathology 2020-03, Vol.76 (4), p.560-571
Main Authors: Akashi, Momoko, Yamaguchi, Rin, Kusano, Hironori, Obara, Hitoshi, Yamaguchi, Miki, Toh, Uhi, Akiba, Jun, Kakuma, Tatsuyuki, Tanaka, Maki, Akagi, Yoshito, Yano, Hirohisa
Format: Article
Language:English
Subjects:
Breast carcinoma
central scar
comedo necrosis
Comedones
ErbB-2 protein
HER2‐positive breast carcinoma
Immune response
Invasiveness
Luteinizing hormone
Lymphocytes
Morphology
Necrosis
oestrogen receptor
Progesterone
Prognosis
Tumors
tumour‐infiltrating lymphocytes
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Summary:Aims HER2‐positive (HER2+) breast carcinoma (BC) cases are often treated similarly; however, they can be classified as either luminal B (LH) or non‐luminal type (NLH) BC, which have different prognoses. In this study, we investigated the clinicohistomorphological features of each HER2+ BC subgroup. Methods and results We classified 166 patients with HER2+ invasive BC into LH (n = 110, 66.3%) and NLH groups (n = 56, 33.7%). We further subclassified LH into patients with carcinomas expressing high levels of hormone receptors [LH‐high; Allred score, oestrogen receptor (ER) and/or progesterone receptor (PgR) 4–8, n = 89, 53.6%] or low levels (LH‐low; Allred score, ER and/or PgR 2 or 3, n = 21, 12.7%) for clinicohistomorphological characterisation. Morphological review showed that NLH included a percentage of patients with comedo necrosis, while LH patients had significantly more central scarring. In terms of immune responsiveness, NLH showed significantly higher rates of tumour‐infiltrating lymphocytes and healing. The LH‐high and NLH groups showed distinct characteristics (by both models, P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.14003