A P53‐related microRNA model for predicting the prognosis of hepatocellular carcinoma patients

Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients’ prognosis. Therefore, we aimed to construct a miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data of 433 patients with HCC from The Cancer Genome...

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Bibliographic Details
Published in:Journal of cellular physiology 2020-04, Vol.235 (4), p.3569-3578
Main Authors: Fang, Shuang‐Sang, Guo, Jin‐Cheng, Zhang, Jian‐Hua, Liu, Jin‐Na, Hong, Shuai, Yu, Bo, Gao, Yuhan, Hu, Su‐Pei, Liu, Hai‐Zhong, Sun, Liang, Zhao, Yi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Cancer
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Datasets
Disease-Free Survival
Female
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Genomes
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
Medical prognosis
microRNA
MicroRNAs
MicroRNAs - genetics
Middle Aged
miRNA
Neoplasm Staging
p53 Protein
Predictions
Prognosis
prognostic model
Rank tests
Regression analysis
Ribonucleic acid
Risk Factors
RNA
Survival
Survival analysis
Time dependence
Transcriptome - genetics
Tumor Suppressor Protein p53 - genetics
Young Adult
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Summary:Studies have shown that microRNAs (miRNAs) play a vital role in tumor progression and patients’ prognosis. Therefore, we aimed to construct a miRNA model for forecasting the survival of hepatocellular carcinoma (HCC) patients. The gene expression data of 433 patients with HCC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus public databases were remined by survival analysis and receptor manipulation characteristic curve (ROC). A prognostic model including six miRNAs (hsa‐mir‐26a‐1‐3p, hsa‐mir‐188‐5p, hsa‐mir‐212‐5p, hsa‐mir‐149‐5p, hsa‐mir‐105‐5p, and hsa‐mir‐132‐5p) were constructed in the training dataset (TCGA, n = 333). HCC patients were stratified into a high‐risk group and a low‐risk group with significantly different survival (median: 2.75 vs. 8.93 years, log‐rank test p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29245