Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review

Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox sta...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2019-08, Vol.23 (8), p.694-699
Main Authors: Martínez Leo, E. E., Segura Campos, M. R.
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Antioxidants - metabolism
Free radicals
Geriatrics/Gerontology
Humans
Inflammation
Medicine
Medicine & Public Health
Neurodegeneration
Neurodegenerative Diseases - etiology
Neurodegenerative Diseases - physiopathology
Neurosciences
Nutrition
Oxidative stress
Oxidative Stress - physiology
Primary Care Medicine
Quality of Life Research
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Summary:Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-019-1240-8