A multimeric MRI contrast agent based on a closo -borane scaffold bearing modified AAZTA chelates on the periphery

A multimeric MRI contrast agent based on the closo -borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo -borane motif using Cu( i ) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AA...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (82), p.12348-12351
Main Authors: Chakravarty, Shatadru, Sarma, Saurav J., Goswami, Lalit N., Cai, Quan-Yu, Shapiro, Erik M., Hawthorne, M. Frederick, Ma, Lixin
Format: Article
Language:English
Subjects:
Alkynes
Chelates
Chemical synthesis
Contrast agents
Gadolinium
In vivo methods and tests
Organic chemistry
Water chemistry
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Summary:A multimeric MRI contrast agent based on the closo -borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo -borane motif using Cu( i ) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro / in vivo .
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05383b