Cell cycle dynamics in the reprogramming of cellular identity

Reprogramming of cellular identity is fundamentally at odds with replication of the genome: cell fate reprogramming requires complex multidimensional epigenomic changes, whereas genome replication demands fidelity. In this review, we discuss how the pace of the genome's replication and cell cyc...

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Bibliographic Details
Published in:FEBS letters 2019-10, Vol.593 (20), p.2840-2852
Main Authors: Hu, Xiao, Eastman, Anna E., Guo, Shangqin
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - genetics
cell cycle speed
Cell Differentiation
cell fate
Cell Lineage - genetics
Cellular Reprogramming - genetics
Chromatin - chemistry
Chromatin - metabolism
Cyclin-Dependent Kinases - genetics
Cyclin-Dependent Kinases - metabolism
DNA Replication
Enhancer of Zeste Homolog 2 Protein - genetics
Enhancer of Zeste Homolog 2 Protein - metabolism
Epigenesis, Genetic
Fibroblasts - cytology
Fibroblasts - metabolism
hematopoietic progenitors
Histones - genetics
Histones - metabolism
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Organ Specificity
pluripotent stem cells
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Summary:Reprogramming of cellular identity is fundamentally at odds with replication of the genome: cell fate reprogramming requires complex multidimensional epigenomic changes, whereas genome replication demands fidelity. In this review, we discuss how the pace of the genome's replication and cell cycle influences the way daughter cells take on their identity. We highlight several biochemical processes that are pertinent to cell fate control, whose propagation into the daughter cells should be governed by more complex mechanisms than simple templated replication. With this mindset, we summarize multiple scenarios where rapid cell cycle could interfere with cell fate copying and promote cell fate reprogramming. Prominent examples of cell fate regulation by specific cell cycle phases are also discussed. Overall, there is much to be learned regarding the relationship between cell fate reprogramming and cell cycle control. Harnessing cell cycle dynamics could greatly facilitate the derivation of desired cell types.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13625