Significant lung injury and its prognostic significance in acute liver failure: A cohort analysis

Background and aims Respiratory failure complicating acute liver failure (ALF) may preclude liver transplantation (LT). We evaluated the association between significant lung injury (SLI) and important clinical outcomes. Methods Retrospective cohort study of 947 ALF patients with chest radiograph (CX...

Full description

Saved in:
Bibliographic Details
Published in:Liver international 2020-03, Vol.40 (3), p.654-663
Main Authors: Dong, Victor, Sun, Ken, Gottfried, Michelle, Cardoso, Filipe S., McPhail, Mark J., Stravitz, R. Todd, Lee, William M., Karvellas, Constantine J.
Format: Article
Language:English
Subjects:
Abnormalities
Acetaminophen
acute liver failure
acute lung injury
ALFSG index
Bilirubin
Cohort analysis
Drug overdose
Injuries
Lactic acid
Liver
Liver failure
Liver transplantation
Lungs
Mercury
Oxygenation
prognosis
Radiographs
Survival
Transplantation
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and aims Respiratory failure complicating acute liver failure (ALF) may preclude liver transplantation (LT). We evaluated the association between significant lung injury (SLI) and important clinical outcomes. Methods Retrospective cohort study of 947 ALF patients with chest radiograph (CXR) and arterial blood gas (ABG) data enrolled in the US Acute Liver Failure Study Group (US‐ALFSG) from January 1998 to December 2016. SLI was defined by moderate hypoxaemia (Berlin classification; PaO2/FiO2 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14268