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Changes in the Regulatory T-Lymphocyte Counts in HIV-Infected Patients with a Discordant Response to Antiretroviral Therapy
We examined HIV-infected patients with different efficacies of immune system restoration during antiretroviral therapy. The study showed that against the background of low CD4+ T cell counts, subjects with a discordant immunologic response (patients with
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| Published in: | Doklady. Biological sciences 2019-07, Vol.487 (1), p.128-131 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 131 |
| container_issue | 1 |
| container_start_page | 128 |
| container_title | Doklady. Biological sciences |
| container_volume | 487 |
| creator | Saidakova, E. V. Shmagel, K. V. Shmagel, N. G. Korolevskaya, L. B. Chereshnev, V. A. |
| description | We examined HIV-infected patients with different efficacies of immune system restoration during antiretroviral therapy. The study showed that against the background of low CD4+ T cell counts, subjects with a discordant immunologic response (patients with |
| doi_str_mv | 10.1134/S0012496619040082 |
| format | article |
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T cells per μL of blood after more than two years of treatment) develop a regulatory CD4
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+
T cells per μL of blood after more than two years of treatment) develop a regulatory CD4
+
T cell (T
reg
) deficiency. Furthermore, in these patients, the immunodeficiency is accompanied by an increase in the T
reg
frequency. Accumulation of regulatory T lymphocytes in the blood of HIV‑infected subjects with discordant response to the treatment indicates a high viability of this T cell subset.</description><subject>Adult</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Biomedical and Life Sciences</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Cell Biology</subject><subject>Drug therapy</subject><subject>Evolutionary Biology</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - drug therapy</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunodeficiency</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Plant Sciences</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><issn>0012-4966</issn><issn>1608-3105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kU9r3DAQxUVoaLZpPkAuRdBLLk70x5asY9gmzcJCS7vN1cjyOHbwSq4kN5h8-WizSQstPQ3D-82bBw-hU0rOKeX5xXdCKMuVEFSRnJCSHaAFFaTMOCXFG7TYydlOP0LvQrgnaSeSv0VHnBaSJn6BHpedtncQcG9x7AB_g7tp0NH5GW-y9bwdO2fmCHjpJhufqZvVbbayLZgIDf6qYw874aGPHdb4Ux-M8422MTmF0dkAODp8aWPvIXr3q_d6wJsOvB7n9-iw1UOAk5d5jH5cX22WN9n6y-fV8nKdGcYVywrJa8N5UwjJCq3qMq85GA2qYIyyRhopytYY0RQtbbVoJdOJk6psalFq0_BjdLb3Hb37OUGI1TbFhGHQFtwUKsaUkkKWtEjox7_Qezd5m9I9U7kUStBE0T1lvAvBQ1uNvt9qP1eUVLtmqn-aSTcfXpynegvN74vXKhLA9kBIUqrE_3n9f9cnipWYNA</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Saidakova, E. 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T cells per μL of blood after more than two years of treatment) develop a regulatory CD4
+
T cell (T
reg
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reg
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| fulltext | fulltext |
| identifier | ISSN: 0012-4966 |
| ispartof | Doklady. Biological sciences, 2019-07, Vol.487 (1), p.128-131 |
| issn | 0012-4966 1608-3105 |
| language | eng |
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| source | Springer Nature |
| subjects | Adult Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antiretroviral drugs Antiretroviral therapy Biomedical and Life Sciences CD4 antigen CD4 Lymphocyte Count Cell Biology Drug therapy Evolutionary Biology Female HIV HIV Infections - blood HIV Infections - drug therapy Human immunodeficiency virus Humans Immune system Immunodeficiency Life Sciences Lymphocytes Lymphocytes T Male Plant Sciences T-Lymphocytes, Regulatory - drug effects |
| title | Changes in the Regulatory T-Lymphocyte Counts in HIV-Infected Patients with a Discordant Response to Antiretroviral Therapy |
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