Assessment of neuron-specific enolase, S100B and malondialdehyde levels in serum and vitreous of patients with proliferative diabetic retinopathy

Purpose To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features. Materials and methods The study...

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Bibliographic Details
Published in:International ophthalmology 2020, Vol.40 (1), p.227-234
Main Authors: Asadova, Vusala, Gul, Zulfiye, Buyukuysal, Rifat Levent, Yalcinbayir, Ozgur
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - metabolism
Diabetic Retinopathy - surgery
Diagnostic systems
Female
Follow-Up Studies
Humans
Male
Malondialdehyde
Malondialdehyde - metabolism
Medicine
Medicine & Public Health
Middle Aged
Neurodegeneration
Ophthalmology
Original Paper
Oxidative Stress
Patients
Phosphopyruvate hydratase
Phosphopyruvate Hydratase - metabolism
Prognosis
Prospective Studies
Retina - pathology
Retinopathy
S100 Calcium Binding Protein beta Subunit - metabolism
S100b protein
Serum levels
Statistical methods
Surgery
Tomography, Optical Coherence
Vitrectomy
Vitreous Body - metabolism
Young Adult
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Summary:Purpose To assess the vitreous and serum levels of neuron-specific enolase (NSE), S100B and malondialdehyde (MDA) in proliferative diabetic retinopathy (PDR) cases and investigate the correlation between preoperative and postoperative anatomical and clinical features. Materials and methods The study group included patients who had pars plana vitrectomy (PPV) for PDR. The control group included non-diabetic individuals who underwent PPV surgery for vitreoretinal interface disorders. Samples of serum were taken from all participants preoperatively, while vitreous samples were taken during the PPV. Vitreous and serum levels of NSE, S100B and MDA were measured, and comparisons were made between the groups. Results The study group consisted of 56 eyes of 56 cases with PDR. The control group consisted of 20 eyes of 20 cases. The concentrations of vitreous NSE, S100B and MDA were significantly higher than the control group ( p  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-019-01175-9