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Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States
Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset. The purpose of this study was to examine the relationship between operator experience and procedural results of TMVr. TMVr device procedures...
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Published in: | Journal of the American College of Cardiology 2019-12, Vol.74 (24), p.2955-2965 |
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creator | Chhatriwalla, Adnan K. Vemulapalli, Sreekanth Szerlip, Molly Kodali, Susheel Hahn, Rebecca T. Saxon, John T. Mack, Michael J. Ailawadi, Gorav Rymer, Jennifer Manandhar, Pratik Kosinski, Andrzej S. Sorajja, Paul |
description | Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset.
The purpose of this study was to examine the relationship between operator experience and procedural results of TMVr.
TMVr device procedures from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy registry were analyzed with operator case number as a continuous and categorical (1 to 25, 26 to 50, and >50) variable. Outcomes of procedural success, procedural time, and in-hospital procedural complications were examined. The learning curve for the procedure was evaluated using generalized linear mixed models adjusting for baseline clinical variables.
All TMVr device procedures (n = 14,923) performed by 562 operators at 290 sites between November 2013 and March 2018 were analyzed. Optimal procedural success (≤1+ residual MR without death or cardiac surgery) increased across categories of operator experience (63.9%, 68.4%, and 75.1%; p |
doi_str_mv | 10.1016/j.jacc.2019.09.014 |
format | article |
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The purpose of this study was to examine the relationship between operator experience and procedural results of TMVr.
TMVr device procedures from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy registry were analyzed with operator case number as a continuous and categorical (1 to 25, 26 to 50, and >50) variable. Outcomes of procedural success, procedural time, and in-hospital procedural complications were examined. The learning curve for the procedure was evaluated using generalized linear mixed models adjusting for baseline clinical variables.
All TMVr device procedures (n = 14,923) performed by 562 operators at 290 sites between November 2013 and March 2018 were analyzed. Optimal procedural success (≤1+ residual MR without death or cardiac surgery) increased across categories of operator experience (63.9%, 68.4%, and 75.1%; p < 0.001), while procedural time and procedural complications decreased. Acceptable procedural success (≤2+ residual MR without death or cardiac surgery) also increased with operator experience, but the differences were smaller (91.4%, 92.4%, and 93.8%; p < 0.001). These associations remained significant in adjusted, continuous variable analyses. Visual inflection points in the learning curves for procedural time, procedural success, and procedural complications were evident after approximately 50 cases, with continued improvements observed out to 200 cases.
For TMVr device procedures, operator experience was associated with improvements in procedural success, procedure time, and procedural complications. The effect of operator experience was greater when considering the goal of achieving 1+ residual MR.
[Display omitted]</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2019.09.014</identifier><identifier>PMID: 31568867</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - instrumentation ; Cardiac Surgical Procedures - statistics & numerical data ; Cardiology ; Clinical outcomes ; Complications ; Continuity (mathematics) ; Endovascular Procedures - adverse effects ; Endovascular Procedures - instrumentation ; Endovascular Procedures - statistics & numerical data ; Female ; Heart ; Heart surgery ; Heart valves ; Humans ; Inflection points ; Learning Curve ; Learning curves ; Male ; mitral regurgitation ; Mitral valve ; Mitral Valve - surgery ; Mitral Valve Insufficiency - surgery ; Mortality ; operator ; Patients ; Registries ; Regurgitation ; Repair ; Statistical models ; Success ; Surgery ; Thorax ; Thrombosis ; TMVr ; Treatment Outcome ; United States ; Variables ; Vascular surgery</subject><ispartof>Journal of the American College of Cardiology, 2019-12, Vol.74 (24), p.2955-2965</ispartof><rights>2019 American College of Cardiology Foundation</rights><rights>Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>2019. American College of Cardiology Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-a14bff30d9352a8b1088c9adbfb5b785595cf6a592ff2dd3f54b9e0a77ae21073</citedby><cites>FETCH-LOGICAL-c428t-a14bff30d9352a8b1088c9adbfb5b785595cf6a592ff2dd3f54b9e0a77ae21073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31568867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chhatriwalla, Adnan K.</creatorcontrib><creatorcontrib>Vemulapalli, Sreekanth</creatorcontrib><creatorcontrib>Szerlip, Molly</creatorcontrib><creatorcontrib>Kodali, Susheel</creatorcontrib><creatorcontrib>Hahn, Rebecca T.</creatorcontrib><creatorcontrib>Saxon, John T.</creatorcontrib><creatorcontrib>Mack, Michael J.</creatorcontrib><creatorcontrib>Ailawadi, Gorav</creatorcontrib><creatorcontrib>Rymer, Jennifer</creatorcontrib><creatorcontrib>Manandhar, Pratik</creatorcontrib><creatorcontrib>Kosinski, Andrzej S.</creatorcontrib><creatorcontrib>Sorajja, Paul</creatorcontrib><title>Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset.
The purpose of this study was to examine the relationship between operator experience and procedural results of TMVr.
TMVr device procedures from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy registry were analyzed with operator case number as a continuous and categorical (1 to 25, 26 to 50, and >50) variable. Outcomes of procedural success, procedural time, and in-hospital procedural complications were examined. The learning curve for the procedure was evaluated using generalized linear mixed models adjusting for baseline clinical variables.
All TMVr device procedures (n = 14,923) performed by 562 operators at 290 sites between November 2013 and March 2018 were analyzed. Optimal procedural success (≤1+ residual MR without death or cardiac surgery) increased across categories of operator experience (63.9%, 68.4%, and 75.1%; p < 0.001), while procedural time and procedural complications decreased. Acceptable procedural success (≤2+ residual MR without death or cardiac surgery) also increased with operator experience, but the differences were smaller (91.4%, 92.4%, and 93.8%; p < 0.001). These associations remained significant in adjusted, continuous variable analyses. Visual inflection points in the learning curves for procedural time, procedural success, and procedural complications were evident after approximately 50 cases, with continued improvements observed out to 200 cases.
For TMVr device procedures, operator experience was associated with improvements in procedural success, procedure time, and procedural complications. The effect of operator experience was greater when considering the goal of achieving 1+ residual MR.
[Display omitted]</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiac Surgical Procedures - instrumentation</subject><subject>Cardiac Surgical Procedures - statistics & numerical data</subject><subject>Cardiology</subject><subject>Clinical outcomes</subject><subject>Complications</subject><subject>Continuity (mathematics)</subject><subject>Endovascular Procedures - adverse effects</subject><subject>Endovascular Procedures - instrumentation</subject><subject>Endovascular Procedures - statistics & numerical data</subject><subject>Female</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Heart valves</subject><subject>Humans</subject><subject>Inflection points</subject><subject>Learning Curve</subject><subject>Learning curves</subject><subject>Male</subject><subject>mitral regurgitation</subject><subject>Mitral valve</subject><subject>Mitral Valve - surgery</subject><subject>Mitral Valve Insufficiency - surgery</subject><subject>Mortality</subject><subject>operator</subject><subject>Patients</subject><subject>Registries</subject><subject>Regurgitation</subject><subject>Repair</subject><subject>Statistical models</subject><subject>Success</subject><subject>Surgery</subject><subject>Thorax</subject><subject>Thrombosis</subject><subject>TMVr</subject><subject>Treatment Outcome</subject><subject>United States</subject><subject>Variables</subject><subject>Vascular surgery</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kM9qFTEUh4NY7G31BVxIwE03c5s_k0kCbqTUKlQuaOtKCJnkBDPMnbkmmaJv02fpk5nrrS5cCAfOgXznx8mH0EtK1pTQ7nxYD9a5NSNUr0kt2j5BKyqEarjQ8ilaEclFQ4mWx-gk54EQ0imqn6FjTkWnVCdX6OtmB8mWOeHLH3WKMDnAdvJ4sxQ3byHjOeCbZKfsbPkGBRL-GEuyI_5ixzvAn2BnY8Jxerivzw_3t1Ms4PHnYgvk5-go2DHDi8d-im7fXd5cvG-uN1cfLt5eN65lqjSWtn0InHjNBbOqp0Qpp63vQy96qYTQwoXOCs1CYN7zINpeA7FSWmC0fvIUnR1yd2n-vkAuZhuzg3G0E8xLNoxpLTvNpa7o63_QYV7SVK8zjDNOBBWtqBQ7UC7NOScIZpfi1qafhhKzd28Gs3dv9u4NqUXbuvTqMXrpt-D_rvyRXYE3BwCqi7sIyWT3W7iPCVwxfo7_y_8FohGWxA</recordid><startdate>20191217</startdate><enddate>20191217</enddate><creator>Chhatriwalla, Adnan K.</creator><creator>Vemulapalli, Sreekanth</creator><creator>Szerlip, Molly</creator><creator>Kodali, Susheel</creator><creator>Hahn, Rebecca T.</creator><creator>Saxon, John T.</creator><creator>Mack, Michael J.</creator><creator>Ailawadi, Gorav</creator><creator>Rymer, Jennifer</creator><creator>Manandhar, Pratik</creator><creator>Kosinski, Andrzej S.</creator><creator>Sorajja, Paul</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20191217</creationdate><title>Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States</title><author>Chhatriwalla, Adnan K. ; 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The purpose of this study was to examine the relationship between operator experience and procedural results of TMVr.
TMVr device procedures from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy registry were analyzed with operator case number as a continuous and categorical (1 to 25, 26 to 50, and >50) variable. Outcomes of procedural success, procedural time, and in-hospital procedural complications were examined. The learning curve for the procedure was evaluated using generalized linear mixed models adjusting for baseline clinical variables.
All TMVr device procedures (n = 14,923) performed by 562 operators at 290 sites between November 2013 and March 2018 were analyzed. Optimal procedural success (≤1+ residual MR without death or cardiac surgery) increased across categories of operator experience (63.9%, 68.4%, and 75.1%; p < 0.001), while procedural time and procedural complications decreased. Acceptable procedural success (≤2+ residual MR without death or cardiac surgery) also increased with operator experience, but the differences were smaller (91.4%, 92.4%, and 93.8%; p < 0.001). These associations remained significant in adjusted, continuous variable analyses. Visual inflection points in the learning curves for procedural time, procedural success, and procedural complications were evident after approximately 50 cases, with continued improvements observed out to 200 cases.
For TMVr device procedures, operator experience was associated with improvements in procedural success, procedure time, and procedural complications. The effect of operator experience was greater when considering the goal of achieving 1+ residual MR.
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subjects | Aged Aged, 80 and over Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - instrumentation Cardiac Surgical Procedures - statistics & numerical data Cardiology Clinical outcomes Complications Continuity (mathematics) Endovascular Procedures - adverse effects Endovascular Procedures - instrumentation Endovascular Procedures - statistics & numerical data Female Heart Heart surgery Heart valves Humans Inflection points Learning Curve Learning curves Male mitral regurgitation Mitral valve Mitral Valve - surgery Mitral Valve Insufficiency - surgery Mortality operator Patients Registries Regurgitation Repair Statistical models Success Surgery Thorax Thrombosis TMVr Treatment Outcome United States Variables Vascular surgery |
title | Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States |
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