Biogenesis and ceRNA role of circular RNAs in skeletal muscle myogenesis

Circular RNAs (circRNAs) are novel endogenous non-coding RNAs that are generated by reverse-splicing of precursor mRNA derived from various genes in mammals. Despite low expression, recent studies have shown that circRNA plays an important role in skeletal muscle myogenesis with competing endogenous...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2019-12, Vol.117, p.105621-105621, Article 105621
Main Authors: Yue, Binglin, Wang, Jian, Song, Chengchuang, Wu, Jiyao, Cao, Xiukai, Huang, Yongzheng, Lan, Xianyong, Lei, Chuzhao, Huang, Bizhi, Chen, Hong
Format: Article
Language:English
Subjects:
ceRNA
circRNA
Skeletal muscle
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Summary:Circular RNAs (circRNAs) are novel endogenous non-coding RNAs that are generated by reverse-splicing of precursor mRNA derived from various genes in mammals. Despite low expression, recent studies have shown that circRNA plays an important role in skeletal muscle myogenesis with competing endogenous RNA (ceRNA) functions. However, the potential regulatory role of circRNAs and interactions with miRNAs remain largely unexplored, and the function of circRNAs as miRNA sponges is not yet generally accepted. In this review, we outline the biogenesis and ceRNA mechanisms of circRNAs as well as their involvement in skeletal muscle myogenesis and discuss the conflicting conclusions of recent circRNA-ceRNA studies.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2019.105621