Discovery and development of azasteroids as anticancer agents

•Cancer is the second leading cause of death following cardiovascular diseases.•Steroids have shown promising results in cancer treatment.•Azasteroids received much attention among structurally modified natural steroids.•The discovery and development of azasteroids as anticancer agents is discussed....

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Bibliographic Details
Published in:Steroids 2019-12, Vol.152, p.108505-108505, Article 108505
Main Authors: Birudukota, Nagaraju, Mudgal, Mukesh Madan, Shanbhag, Venkatesh
Format: Article
Language:English
Subjects:
4-Azasteroids
Anticancer
Azasteroids
N-glycosides
Nitrogen mustards
Steroids
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Summary:•Cancer is the second leading cause of death following cardiovascular diseases.•Steroids have shown promising results in cancer treatment.•Azasteroids received much attention among structurally modified natural steroids.•The discovery and development of azasteroids as anticancer agents is discussed. Cancer is the second leading cause of death worldwide following cardiovascular diseases. Cancer can be treated by a variety of techniques including surgery, radiation therapy, immunotherapy, and chemotherapy. Choice of the method can be made based on type, physiologic location and the stage of disease progression. Among chemical methods, steroids find broad applications. Azasteroids have N- substitutions in steroidal rings. This structural modification renders azasteroids advantageous in increased effectiveness and reduced side effects. Numerous accounts of cancer efficacy of this family of compounds are available in literature. The progress made in the discovery, synthetic efforts and development of azasteroids as anticancer agents is broadly outlined in this review.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2019.108505