Stereoselective C(sp2)–H Alkylation of Enamides with Unactivated Aliphatic Carboxylic Acids via Decarboxylative Cross-Coupling Reactions

An efficient and straightforward stereoselective alkylation reaction of enamides using commercially available and easily accessible unactivated alkyl carboxylic acids as alkylating agents is described, giving rise to a diverse array of synthetically important and geometrically defined β-alkylated en...

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Bibliographic Details
Published in:Organic letters 2019-10, Vol.21 (20), p.8395-8399
Main Authors: Guo, Jing-Yu, Guan, Ting, Tao, Ji-Yu, Zhao, Kai, Loh, Teck-Peng
Format: Article
Language:English
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Summary:An efficient and straightforward stereoselective alkylation reaction of enamides using commercially available and easily accessible unactivated alkyl carboxylic acids as alkylating agents is described, giving rise to a diverse array of synthetically important and geometrically defined β-alkylated enamides bearing primary, secondary, or tertiary alkyl moieties. This transformation also shows excellent functional group tolerance, satisfying atom economy, and operational simplicity.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03169