Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ

Abstract The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and b...

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Bibliographic Details
Published in:Nutrition reviews 2020-03, Vol.78 (3), p.207-214
Main Authors: da Cruz, Beatriz O, Cardozo, Ludmila F M de França, Magliano, D’Angelo C, Stockler-Pinto, Milena B
Format: Article
Language:English
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Summary:Abstract The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms a heterodimer with the retinoic acid receptor and binds to peroxisome proliferator response elements to initiate transcription of its target genes. PPARβ/δ is also able to suppress the activities of several transcription factors, including nuclear factor κB, and activator protein 1, thus regulating anti-inflammatory cellular responses and playing a protective role in several diseases. Recent studies have shown that nutritional compounds, including nutrients and bioactive compounds, can regulate PPARβ/δ expression. This review discusses key nutritional compounds that are known to modulate PPARβ/δ and are likely to affect human health.
ISSN:0029-6643
1753-4887
DOI:10.1093/nutrit/nuz058