Association of NFκB and related-cytokines with the viral load and development of antibodies against HHV-8 in people living with HIV/AIDS

• Published in: Medical microbiology and immunology 2020-02, Vol.209 (1), p.41-49
• Main Authors: Gonçales, Juliana Prado, Lopes, Thaísa Regina Rocha, de Lorena, Virginia Maria Barros, Aciole, Melayne Rocha, Silva Júnior, José Valter Joaquim, Tozetto-Mendoza, Tania Regina, Braz-Silva, Paulo Henrique, Coêlho, Maria Rosangela Cunha Duarte
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Activation; AIDS; Antibodies; Antigens; Antiretroviral drugs; Biomedical and Life Sciences; Biomedicine; CD19 antigen; CD3 antigen; Cytokines; HIV; Human immunodeficiency virus; IL-1β; Immune response; Immunoglobulins; Immunology; Inflammation; Inflammatory response; Interleukin 12; Lymphocytes; Lymphocytes B; Lymphocytes T; Medical Microbiology; NF-κB protein; Original Investigation; Replication; Tumor necrosis factor-α; Virology
• ISSN: 0300-8584; 1432-1831
• DOI: 10.1007/s00430-019-00637-2

Human gammaherpesvirus 8 (HHV-8) replication is influenced by a complex interaction between viral and host elements. Here, we evaluated the expression of NFκB and TNF-α in B (CD19 +) and T (CD3 +) lymphocytes, and the serum concentration of IL-1β and IL-12 cytokines in people living with HIV/AIDS (PLHA), negative for HHV-8-related diseases, and who presented antibodies to latent or lytic antigens from HHV-8. In addition, we also evaluated the correlation of HHV-8 viral load with NFκB, TNF-α, IL-1β and IL-12 levels. The expression of NFκB ( p