Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming

Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultane...

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Bibliographic Details
Published in:Cell stem cell 2019-10, Vol.25 (4), p.451-453
Main Authors: Hu, Xiao, Guo, Shangqin
Format: Article
Language:English
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Summary:Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame. Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2019.09.007