Effect of the Bruder moist heat eye compress on contact lens discomfort in contact lens wearers: An open-label randomized clinical trial

The purpose of this study was to investigate the effect of the Bruder Moist Heat Compress on contact lens (CL) discomfort in subjects with contact lens-related dry eye (CLDE). This was a 4-week, single-center, three-arm, randomized, open-label clinical trial in subjects diagnosed with CLDE using the...

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Bibliographic Details
Published in:Contact lens & anterior eye 2019-12, Vol.42 (6), p.625-632
Main Authors: Tichenor, Anna A., Cox, Stephanie M., Ziemanski, Jillian F., Ngo, William, Karpecki, Paul M., Nichols, Kelly K., Nichols, Jason J.
Format: Article
Language:English
Subjects:
Adult
Clinical trial
Contact lens discomfort
Contact Lenses, Hydrophilic - adverse effects
Dry eye
Dry Eye Syndromes - etiology
Dry Eye Syndromes - physiopathology
Dry Eye Syndromes - therapy
Female
Humans
Hyperthermia, Induced
Lipid Metabolism - physiology
Male
Meibomian gland
Middle Aged
Surveys and Questionnaires
Tears - physiology
Time Factors
Warm compress
Young Adult
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Summary:The purpose of this study was to investigate the effect of the Bruder Moist Heat Compress on contact lens (CL) discomfort in subjects with contact lens-related dry eye (CLDE). This was a 4-week, single-center, three-arm, randomized, open-label clinical trial in subjects diagnosed with CLDE using the Contact Lens Dry Eye Questionnaire. Fifty-one CL wearers were randomized to one of three treatment groups: application of the Bruder Compress twice a day, Bruder Compress once a day, or warm washcloth used for ten minutes twice a day without reheating. Subject diaries were monitored for compliance and collected data on daily CL comfort upon awakening and throughout the afternoon. Clinical assessments included tear film break-up time (TBUT), lipid layer thickness (LLT), and meibomian gland evaluation. Statistical tests included a generalized linear model and one-way analysis of variance (ANOVA) to investigate treatment effect on comfortable wear time. Fifty-one subjects (98% female) completed the study. After treatment, subjects using a washcloth reported more uncomfortable contact lens wear time on average (mean = 5.1 ± 2.8 h) when compared with subjects who had used the Bruder Compress in Group 1 (mean = 2.8 ± 1.6 h) (p = 0.02). In the Bruder Compress groups, there was a significant reduction in the blockage of meibomian glands (p 
ISSN:1367-0484
1476-5411
DOI:10.1016/j.clae.2019.09.005