Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA study

• Published in: Diabetes research and clinical practice 2019-11, Vol.157, p.107876-107876, Article 107876
• Main Authors: Cheng, E., Longmore, D.K., Barzi, F., Barr, E.L.M., Lee, I.L., Whitbread, C., Boyle, J.A., Oats, J., Connors, C., McIntyre, H.D., Kirkwood, M., Dempsey, K., Zhang, X., Thomas, S., Williams, D., Zimmet, P., Brown, A.D.H., Shaw, J.E., Maple-Brown, L.J.
• Format: Article
• Language: English
• Subjects: Aboriginal and Torres Strait Islander; Adolescent; Adult; Birth Weight - genetics; Diabetes, Gestational - therapy; Female; Gestational diabetes mellitus; Humans; Hyperglycaemia in pregnancy; Induction of labour; Life Style; Lifestyle modification; Pregnancy; Pregnancy Complications - therapy; Young Adult
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2019.107876

To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy. Indigenous (n = 97) and Europid (n = 113) women managed by lifestyle modification were compared to women without hyperglycaemia (n = 235). Multivariate linear and logistic regressions assessed whether GDM-lifestyle women had poorer outcomes compared to women without hyperglycaemia. Women with GDM-lifestyle had higher body mass index and lower gestational weight gain than women without hyperglycaemia. On univariate analysis, gestational age at delivery was lower and induction rates were higher in women with GDM-lifestyle than without hyperglycaemia. On multivariable regression, GDM-lifestyle was associated with lower gestational age at delivery (by 0.73 weeks), lower birthweight z-score (by 0.26, p = 0.007), lower likelihood of large for gestational age (LGA) [OR (95% CI): 0.55 (0.28, 1.02), p = 0.059], and greater likelihood of labour induction [2.34 (1.49, 3.66), p