Enantioselective Conjugate Addition of Aryl Halides and Triflates to Electron-Deficient Olefins via Nickel- and Rhodium-Catalyzed Sequential Relay Reactions

Asymmetric conjugate addition of aryl halides or aryl triflates to electron-deficient olefins was realized by sequential Miyaura borylation and Hayashi–Miyaura conjugate addition in one pot. A nickel-catalyzed borylation of aryl halides or triflates and a rhodium–chiral diene complex catalyzed enant...

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Bibliographic Details
Published in:Organic letters 2019-11, Vol.21 (22), p.8888-8892
Main Authors: Fan, Chenrui, Wu, Qixu, Zhu, Chengfeng, Wu, Xiang, Li, Yougui, Luo, Yunfei, He, Jian-Bo
Format: Article
Language:English
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Summary:Asymmetric conjugate addition of aryl halides or aryl triflates to electron-deficient olefins was realized by sequential Miyaura borylation and Hayashi–Miyaura conjugate addition in one pot. A nickel-catalyzed borylation of aryl halides or triflates and a rhodium–chiral diene complex catalyzed enantioselective conjugate addition was executed as a pair of relay reactions as a more efficient and greener protocol.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02940