Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides

A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C­(sp)–C­(sp2) and C­(sp2)N bonds were constructed in one pot. This reaction featured in h...

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Bibliographic Details
Published in:Organic letters 2019-10, Vol.21 (20), p.8439-8443
Main Authors: Li, Meng, Fang, Songjia, Zheng, Jia, Jiang, Huanfeng, Wu, Wanqing
Format: Article
Language:English
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Summary:A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C­(sp)–C­(sp2) and C­(sp2)N bonds were constructed in one pot. This reaction featured in high efficiency, excellent chemoselectivity, and good functional group compatibility. The synthetic utility of this method was also demonstrated.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03201