Reproductive factors and thyroid cancer risk: Meta‐analysis

Background Assessed pooled risk on reproductive factors and oral contraceptives (OC) on thyroid cancer (TC) using published studies (1996‐2017). Methods Summary odds ratio (OR) for case‐control studies (n = 10) and risk ratio (RR) for cohort studies (n = 9) was done. Results OR was 1.43 (95% CI: 1.1...

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Bibliographic Details
Published in:Head & neck 2019-12, Vol.41 (12), p.4199-4208
Main Authors: Mannathazhathu, Arathy S., George, Preethi S., Sudhakaran, Sreekala, Vasudevan, Durga, Krishna KM, Jagathnath, Booth, Christopher, Mathew, Aleyamma
Format: Article
Language:English
Subjects:
Abortion
Head and neck
Health risk assessment
Menarche
Menopause
Menstrual cycle
Meta-analysis
Miscarriage
oral contraceptive use
Oral contraceptives
Parity
Pregnancy
reproductive factors
Thyroid cancer
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Summary:Background Assessed pooled risk on reproductive factors and oral contraceptives (OC) on thyroid cancer (TC) using published studies (1996‐2017). Methods Summary odds ratio (OR) for case‐control studies (n = 10) and risk ratio (RR) for cohort studies (n = 9) was done. Results OR was 1.43 (95% CI: 1.16‐1.77) for age at menarche >14 years, 1.49 (95% CI: 1.19‐1.86) for parity >2, 1.38 (95% CI: 1.18‐1.61) for miscarriage/abortion, and 2.05 (95% CI: 1.39‐3.01) for artificial menopause. A protective effect (ORs: 0.85; 95% CI: 0.72‐0.99) on TC was observed for prolonged use of OCs. RR was 1.17 (95% CI: 0.90‐1.57) for age at menarche >14 years, 1.10 (95% CI: 0.94‐1.27) for parity >2, 1.20 (95% CI: 1.03‐1.40) for miscarriage/abortion, and 2.16 (95% CI: 1.41‐3.31) for artificial menopause and protective effect (RR: 0.78; 95% CI: 0.65‐0.92) for prolonged use of OCs. Conclusions This meta‐analysis supports an association due to changes in female hormones during menstrual cycle and pregnancy with the risk of TC and explains female preponderance.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25945