Neuropsychological function in children with hemophilia: A review of the Hemophilia Growth and Development Study and introduction of the current eTHINK study

Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric blood & cancer 2020-01, Vol.67 (1), p.e28004-n/a
Main Authors: Buranahirun, Cathy, Walsh, Karin S., Mrakotsky, Christine, Croteau, Stacy E., Rajpurkar, Madhvi, Kearney, Susan, Hannemann, Cara, Wilkening, Greta N., Shapiro, Kevin A., Cooper, David L.
Format: Article
Language:English
Subjects:
Child
Child Development
Cognitive ability
Developmental Disabilities - etiology
Developmental Disabilities - pathology
Hematology
Hemophilia
Hemophilia A - complications
Hemophilia A - pathology
Hemophilia A - psychology
HIV
Human immunodeficiency virus
Humans
Intelligence
Neurodevelopment
neuroimaging
neurology
Neuropsychology
Pediatrics
Prophylaxis
Psychomotor Performance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Almost all of what is known about neurologic and cognitive development in hemophilia derives from the Hemophilia Growth and Development Study, conducted during an era when treatment regimens and comorbidities differed significantly from the current environment. Results suggested hemophilia and human immunodeficiency virus had independent effects, and hemophilia negatively impacts academic achievement, attention, and behavior. The introduction of prophylaxis treatment in hemophilia has created the need for re‐evaluation of the effects of hemophilia on neurodevelopment and cognition. We outline the Evolving Treatment of Hemophilia's Impact on Neurodevelopment, Intelligence, and Other Cognitive Functions (NCT03660774) study, which aims to meet this need.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.28004