Legume lectins: Potential use as a diagnostics and therapeutics against the cancer

Legume lectins are carbohydrate-binding protein and widely distributed in a variety of species of leguminous plants and have drawn increased attention toward cancer. Nowadays, the lectins have been studied for the screening of potential biomarkers which increased its importance in cancer research. F...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-01, Vol.142, p.474-483
Main Authors: Gautam, Ajay Kumar, Sharma, Divakar, Sharma, Juhi, Saini, Khem Chand
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Cancer cell lines
Legume lectins
Therapeutics
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Summary:Legume lectins are carbohydrate-binding protein and widely distributed in a variety of species of leguminous plants and have drawn increased attention toward cancer. Nowadays, the lectins have been studied for the screening of potential biomarkers which increased its importance in cancer research. Few plant lectins have been shown to destroy cancer cells, suggesting that lectins may have biological potential in cancer treatments. In this review, we present a focused outline of legume lectins in descriptive their complex anti-cancer mechanisms on the bases of their properties of recognition and interacting specifically with carbohydrates binding sites. Existing reports suggested the binding of lectins to cancerous cells with their cell surface markers speculated by histochemistry in vitro and in vivo. In this review, we illuminate the use of legume lectins as a natural source for diagnostics and therapeutics purpose against cancer.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2019.09.119