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Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study
Purpose To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT). Methods Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2019-10, Vol.257 (10), p.2315-2322 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Yang, Min Kyu Kim, Namju Choung, Ho-Kyung In Khwarg, Sang |
| description | Purpose
To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT).
Methods
Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3 months were recruited and treated with a topical steroid for 3 months. Tear meniscus height (TMH) and area (TMA) were measured by ASOCT. The treatment was considered to be effective when there was improvement of subjective epiphora, normal tear meniscus on slit lamp examination, a fluorescein dye disappearance test with grade 0 or 1, and TMH |
| doi_str_mv | 10.1007/s00417-019-04392-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2303210249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2303210249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-cdbe937eccf922901154f555ba7904310c7a1e82d15f05218f10be08f852585d3</originalsourceid><addsrcrecordid>eNp9kUFrFTEUhYMo9rX6B1xIwI2b0XuTiZlxJ6VWoeBGobswk9y0U2aSMckIb-F_N6-vKrhwlUC-c87NPYy9QHiDAPptBmhRN4B9A63sRYOP2A5bqRoN4vox24EW2HRSXJ-w05zvoPJS4VN2IlG2Alu9Yz8vvCdbePS8xHWyw8xzoRQnl3kMPJGlUOY9d_SD5riS41OwcVlnKsTDkOM82DQtVea2g82YS6qXKYb3PK7l3tDGW0oULNWIJd6kYb3d15TN7Z-xJ36YMz1_OM_Yt48XX88_NVdfLj-ff7hqrNSqNNaN1EtN1vpeiB4QVeuVUuOg-_olBKsHpE44VB6UwM4jjASd75RQnXLyjL0--q4pft8oF7NM2dI8D4Hilo2QIAWCaPuKvvoHvYtbCnU6I8Q7WZethaiUOFI2xZwTebMetpD2BsEcyjHHckzlzX05Bqvo5YP1Ni7k_kh-t1EBeQRyfQo3lP5m_8f2F3zCm-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2263019722</pqid></control><display><type>article</type><title>Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study</title><source>Springer Nature</source><creator>Yang, Min Kyu ; Kim, Namju ; Choung, Ho-Kyung ; In Khwarg, Sang</creator><creatorcontrib>Yang, Min Kyu ; Kim, Namju ; Choung, Ho-Kyung ; In Khwarg, Sang</creatorcontrib><description>Purpose
To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT).
Methods
Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3 months were recruited and treated with a topical steroid for 3 months. Tear meniscus height (TMH) and area (TMA) were measured by ASOCT. The treatment was considered to be effective when there was improvement of subjective epiphora, normal tear meniscus on slit lamp examination, a fluorescein dye disappearance test with grade 0 or 1, and TMH < 250 μm on ASOCT. The treatment effectiveness and associated factors were analyzed.
Results
Treatment was effective in 24 eyes (49.0%) after 6 months of follow-up. TMH and TMA at 3 months were significantly decreased in the effective group on ASOCT (TMH: from 385 to 268 μm,
p
= 0.002, TMA: from 0.0564 to 0.0266 mm
2
,
p
= 0.001, Wilcoxon test). In the effective group, the eyes with normal tear meniscus at 1 month were significantly more frequent than those in the ineffective group (
p
< 0.001, Fisher’s exact test). No patient in the effective group required further invasive management during 3 years of follow-up.
Conclusions
Topical steroid instillation has a significant therapeutic effect on recently developed incomplete NLDO. Additional invasive procedures were avoided in half of the subjects.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-019-04392-1</identifier><identifier>PMID: 31342147</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Administration, Topical ; Dexamethasone - administration & dosage ; Dose-Response Relationship, Drug ; Female ; Fluorescein ; Follow-Up Studies ; Glucocorticoids - administration & dosage ; Humans ; Lacrimal Duct Obstruction - diagnosis ; Lacrimal Duct Obstruction - drug therapy ; Lacrimal gland and Nasolacrimal duct ; Male ; Medicine ; Medicine & Public Health ; Meniscus ; Middle Aged ; Nasolacrimal Duct - diagnostic imaging ; Oculoplastics and Orbit ; Ophthalmology ; Prospective Studies ; Slit Lamp Microscopy ; Steroid hormones ; Time Factors ; Tomography ; Tomography, Optical Coherence - methods ; Treatment Outcome</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2019-10, Vol.257 (10), p.2315-2322</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Graefe's Archive for Clinical and Experimental Ophthalmology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cdbe937eccf922901154f555ba7904310c7a1e82d15f05218f10be08f852585d3</citedby><cites>FETCH-LOGICAL-c375t-cdbe937eccf922901154f555ba7904310c7a1e82d15f05218f10be08f852585d3</cites><orcidid>0000-0002-4815-0804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31342147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Min Kyu</creatorcontrib><creatorcontrib>Kim, Namju</creatorcontrib><creatorcontrib>Choung, Ho-Kyung</creatorcontrib><creatorcontrib>In Khwarg, Sang</creatorcontrib><title>Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT).
Methods
Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3 months were recruited and treated with a topical steroid for 3 months. Tear meniscus height (TMH) and area (TMA) were measured by ASOCT. The treatment was considered to be effective when there was improvement of subjective epiphora, normal tear meniscus on slit lamp examination, a fluorescein dye disappearance test with grade 0 or 1, and TMH < 250 μm on ASOCT. The treatment effectiveness and associated factors were analyzed.
Results
Treatment was effective in 24 eyes (49.0%) after 6 months of follow-up. TMH and TMA at 3 months were significantly decreased in the effective group on ASOCT (TMH: from 385 to 268 μm,
p
= 0.002, TMA: from 0.0564 to 0.0266 mm
2
,
p
= 0.001, Wilcoxon test). In the effective group, the eyes with normal tear meniscus at 1 month were significantly more frequent than those in the ineffective group (
p
< 0.001, Fisher’s exact test). No patient in the effective group required further invasive management during 3 years of follow-up.
Conclusions
Topical steroid instillation has a significant therapeutic effect on recently developed incomplete NLDO. Additional invasive procedures were avoided in half of the subjects.</description><subject>Administration, Topical</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fluorescein</subject><subject>Follow-Up Studies</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Humans</subject><subject>Lacrimal Duct Obstruction - diagnosis</subject><subject>Lacrimal Duct Obstruction - drug therapy</subject><subject>Lacrimal gland and Nasolacrimal duct</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meniscus</subject><subject>Middle Aged</subject><subject>Nasolacrimal Duct - diagnostic imaging</subject><subject>Oculoplastics and Orbit</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Slit Lamp Microscopy</subject><subject>Steroid hormones</subject><subject>Time Factors</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Treatment Outcome</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrFTEUhYMo9rX6B1xIwI2b0XuTiZlxJ6VWoeBGobswk9y0U2aSMckIb-F_N6-vKrhwlUC-c87NPYy9QHiDAPptBmhRN4B9A63sRYOP2A5bqRoN4vox24EW2HRSXJ-w05zvoPJS4VN2IlG2Alu9Yz8vvCdbePS8xHWyw8xzoRQnl3kMPJGlUOY9d_SD5riS41OwcVlnKsTDkOM82DQtVea2g82YS6qXKYb3PK7l3tDGW0oULNWIJd6kYb3d15TN7Z-xJ36YMz1_OM_Yt48XX88_NVdfLj-ff7hqrNSqNNaN1EtN1vpeiB4QVeuVUuOg-_olBKsHpE44VB6UwM4jjASd75RQnXLyjL0--q4pft8oF7NM2dI8D4Hilo2QIAWCaPuKvvoHvYtbCnU6I8Q7WZethaiUOFI2xZwTebMetpD2BsEcyjHHckzlzX05Bqvo5YP1Ni7k_kh-t1EBeQRyfQo3lP5m_8f2F3zCm-g</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Yang, Min Kyu</creator><creator>Kim, Namju</creator><creator>Choung, Ho-Kyung</creator><creator>In Khwarg, Sang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4815-0804</orcidid></search><sort><creationdate>20191001</creationdate><title>Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study</title><author>Yang, Min Kyu ; Kim, Namju ; Choung, Ho-Kyung ; In Khwarg, Sang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cdbe937eccf922901154f555ba7904310c7a1e82d15f05218f10be08f852585d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Administration, Topical</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fluorescein</topic><topic>Follow-Up Studies</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Humans</topic><topic>Lacrimal Duct Obstruction - diagnosis</topic><topic>Lacrimal Duct Obstruction - drug therapy</topic><topic>Lacrimal gland and Nasolacrimal duct</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meniscus</topic><topic>Middle Aged</topic><topic>Nasolacrimal Duct - diagnostic imaging</topic><topic>Oculoplastics and Orbit</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Slit Lamp Microscopy</topic><topic>Steroid hormones</topic><topic>Time Factors</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Min Kyu</creatorcontrib><creatorcontrib>Kim, Namju</creatorcontrib><creatorcontrib>Choung, Ho-Kyung</creatorcontrib><creatorcontrib>In Khwarg, Sang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Min Kyu</au><au>Kim, Namju</au><au>Choung, Ho-Kyung</au><au>In Khwarg, Sang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>257</volume><issue>10</issue><spage>2315</spage><epage>2322</epage><pages>2315-2322</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To evaluate the effect of a topical steroid instillation on recently developed incomplete nasolacrimal duct obstruction (NLDO) evaluated by using anterior segment optical coherence tomography (ASOCT).
Methods
Forty-nine eyes of 31 patients with incomplete NLDO who developed epiphora within 3 months were recruited and treated with a topical steroid for 3 months. Tear meniscus height (TMH) and area (TMA) were measured by ASOCT. The treatment was considered to be effective when there was improvement of subjective epiphora, normal tear meniscus on slit lamp examination, a fluorescein dye disappearance test with grade 0 or 1, and TMH < 250 μm on ASOCT. The treatment effectiveness and associated factors were analyzed.
Results
Treatment was effective in 24 eyes (49.0%) after 6 months of follow-up. TMH and TMA at 3 months were significantly decreased in the effective group on ASOCT (TMH: from 385 to 268 μm,
p
= 0.002, TMA: from 0.0564 to 0.0266 mm
2
,
p
= 0.001, Wilcoxon test). In the effective group, the eyes with normal tear meniscus at 1 month were significantly more frequent than those in the ineffective group (
p
< 0.001, Fisher’s exact test). No patient in the effective group required further invasive management during 3 years of follow-up.
Conclusions
Topical steroid instillation has a significant therapeutic effect on recently developed incomplete NLDO. Additional invasive procedures were avoided in half of the subjects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31342147</pmid><doi>10.1007/s00417-019-04392-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4815-0804</orcidid></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2019-10, Vol.257 (10), p.2315-2322 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | Springer Nature |
| subjects | Administration, Topical Dexamethasone - administration & dosage Dose-Response Relationship, Drug Female Fluorescein Follow-Up Studies Glucocorticoids - administration & dosage Humans Lacrimal Duct Obstruction - diagnosis Lacrimal Duct Obstruction - drug therapy Lacrimal gland and Nasolacrimal duct Male Medicine Medicine & Public Health Meniscus Middle Aged Nasolacrimal Duct - diagnostic imaging Oculoplastics and Orbit Ophthalmology Prospective Studies Slit Lamp Microscopy Steroid hormones Time Factors Tomography Tomography, Optical Coherence - methods Treatment Outcome |
| title | Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study |
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