Efficient and environmentally sustainable domino protocol for the synthesis of diversified spiroheterocycles with privileged heterocyclic substructures using bio-organic catalyst in aqueous medium

An efficient and environmentally sustainable synthetic protocol has been presented to synthesize structurally diverse spiroxindoles spiroannulated with indenopyrroloimidazoles, pyranopyrroloimidazoles, chromenopyrroloimidazoles, and imidazopyrrolopyrimidines involving three-component reaction of isa...

Full description

Saved in:
Bibliographic Details
Published in:Molecular diversity 2020-11, Vol.24 (4), p.1355-1365
Main Authors: Verma, Kanchan, Tailor, Yogesh Kumar, Khandelwal, Sarita, Rushell, Esha, Agarwal, Monu, Kumar, Mahendra
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Life Sciences
Organic Chemistry
Original Article
Pharmacy
Polymer Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient and environmentally sustainable synthetic protocol has been presented to synthesize structurally diverse spiroxindoles spiroannulated with indenopyrroloimidazoles, pyranopyrroloimidazoles, chromenopyrroloimidazoles, and imidazopyrrolopyrimidines involving three-component reaction of isatins, hydantoin, and β-diketones in the presence of green and sustainable bio-organic catalyst, β-amino acid, 2-aminoethanesulfonic acid (taurine), in aqueous media. The synthetic efficiency, operational simplicity, and reusability of catalyst make the present synthetic protocol cost effective, time efficient, and eco-friendly to synthesize molecules with structural diversity and molecular complexity and expected to contribute significantly not only to drug discovery research but also to pharmaceutical and medicinal chemistry.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-019-09999-4