Efficacy of educational intervention on reducing the inappropriate use of oral third-generation cephalosporins

Purpose This study aimed to evaluate the efficacy of an educational intervention on reducing the inappropriate use of oral third-generation cephalosporins, the prevalence of resistant bacteria, and clinical outcomes. Methods A before-after study was conducted to compare the data for 1 year before an...

Full description

Saved in:
Bibliographic Details
Published in:Infection 2019-12, Vol.47 (6), p.1037-1045
Main Authors: Uda, Atsushi, Kimura, Takeshi, Nishimura, Sho, Ebisawa, Kei, Ohji, Goh, Kusuki, Mari, Yahata, Mariko, Izuta, Rie, Sakaue, Tomoyuki, Nakamura, Tatsuya, Koike, Chihiro, Tokimatsu, Issei, Yano, Ikuko, Iwata, Kentaro, Miyara, Takayuki
Format: Article
Language:English
Subjects:
Ampicillin
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteria
Cephalosporins
Cephalosporins - therapeutic use
Drug Resistance, Bacterial
E coli
Education
Family Medicine
Fluoroquinolones
General Practice
Hospitals, University - statistics & numerical data
Inappropriate Prescribing - prevention & control
Incidence
Infectious Diseases
Internal Medicine
Intervention
Japan
Medical personnel
Medicine
Medicine & Public Health
Mortality
Original Paper
Penicillin
Streptococcus infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose This study aimed to evaluate the efficacy of an educational intervention on reducing the inappropriate use of oral third-generation cephalosporins, the prevalence of resistant bacteria, and clinical outcomes. Methods A before-after study was conducted to compare the data for 1 year before and after intervention at a Japanese university hospital. Educational intervention included lectures for all medical staff on oral antibiotics and educational meetings with each medical department. The primary outcome was the use of oral third-generation cephalosporins in inpatients as measured by the monthly median days of therapy (DOTs) per 1000 patient days. Secondary outcomes included the use of each oral antibiotic in inpatients and outpatients, proportion of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), penicillin-resistant Streptococcus pneumoniae (PRSP) and extended-spectrum β-lactamase producing Escherichia coli (ESBLEC), the incidence of hospital-acquired Clostridioides difficile infection (HA-CDI), and hospital mortality. Results The use of oral third-generation cephalosporins in inpatients was significantly decreased after intervention [DOTs (interquartile range): 24.2 (23.5–25.1) vs. 3.7 (0.0–7.1), P  
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-019-01362-x