Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in Mus musculus testis

•PACAP and receptors in mouse testis: molecular and immunohistochemical investigations.•PACAP and its receptors are widely represented in germ and Leydig cells.•We suggest their involvement in the control of spermatogenesis and steroidogenesis. To enlighten the involvement of PACAP/receptors system...

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Bibliographic Details
Published in:General and comparative endocrinology 2020-01, Vol.286, p.113297-113297, Article 113297
Main Authors: Prisco, Marina, Rosati, Luigi, Morgillo, Eliana, Mollica, Maria Pina, Agnese, Marisa, Andreuccetti, Piero, Valiante, Salvatore
Format: Article
Language:English
Subjects:
Animals
Male
Male gametogenesis control
Mice
Mus musculus
PACAP receptors
Pituitary adenylate cyclase-activating peptide (PACAP)
Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism
Testis - metabolism
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Summary:•PACAP and receptors in mouse testis: molecular and immunohistochemical investigations.•PACAP and its receptors are widely represented in germ and Leydig cells.•We suggest their involvement in the control of spermatogenesis and steroidogenesis. To enlighten the involvement of PACAP/receptors system in the control of mammal testis, we investigated the expression of PACAP and the localization of PACAP and its receptors PAC1, VPAC1, and VPAC2 in the testis of Mus musculus. By molecular and immunohistochemical investigations, we highlighted that PACAP and its receptors are widely represented in germ cells of Mus testis, particularly in spermatocytes I, spermatids, and spermatozoa, strongly suggesting their involvement in spermatogenesis process. Moreover, for the first time in the adult mouse testis we highlighted that PACAP is present within Leydig cells, as PACAP receptors, confirming its involvement in the control of steroidogenesis in mouse.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2019.113297