Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

•Toxic were examined in human liver cancer cells and human normal liver cells.•Cells morphologies were analyzed by employing multiple methods.•Ginseng rust rot epidermis shows enhanced anti-cancer activity and little toxicity.•Anti-cancer action was ascribed to the collapse of the cellular membrane...

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Published in:Micron (Oxford, England : 1993) England : 1993), 2019-09, Vol.124, p.102710-102710, Article 102710
Main Authors: Hu, Jing, Jiao, Jie, Wang, Ying, Gao, Mingyan, Lu, Zhengcheng, Yang, Fan, Hu, Cuihua, Song, Zhengxun, Chen, Yujuan, Wang, Zuobin
Format: Article
Language:English
Subjects:
actin
Anti-tumor effect
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
apoptosis
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - pathology
Cell Membrane - drug effects
death
drug development
Drug Discovery
Ginseng-extracted compounds
Hep G2 Cells
Hepatocelluar carcinoma
hepatocytes
hepatoma
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - pathology
neoplasm cells
Panax
Panax - chemistry
Plant Extracts - pharmacology
survival rate
traditional medicine
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Summary:•Toxic were examined in human liver cancer cells and human normal liver cells.•Cells morphologies were analyzed by employing multiple methods.•Ginseng rust rot epidermis shows enhanced anti-cancer activity and little toxicity.•Anti-cancer action was ascribed to the collapse of the cellular membrane in cells. Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.
ISSN:0968-4328
1878-4291
DOI:10.1016/j.micron.2019.102710