The prognosis value of C-reactive protein and endothelin-1 in chronic obstructive pulmonary disease patients with pulmonary artery pressure

Chronic Obstructive Pulmonary Disease (COPD), which is caused by various proinflammatory cytokines, will present some kinds of complication with progression such as Pulmonary Artery Hypertension (PAH). CRP (C-Reactive Protein) and ET-1(Endotheline-1) play pivotal function in inflammatory responses....

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2019-07, Vol.32 (4), p.1697-1701
Main Authors: Yan, Fang, Pidayi, Muyeshaer, Xia, Yu, Hu, Xin, Yang, Zengrong
Format: Article
Language:English
Subjects:
Aged
Ambrisentan
Biomarkers - blood
Body Mass Index
Bosentan
Breath Tests
C-reactive protein
C-Reactive Protein - analysis
Case-Control Studies
Chronic obstructive lung disease
Endothelin
Endothelin-1 - blood
Endothelin-1 - metabolism
Exercise
Female
Humans
Hypertension
Hypertension, Pulmonary - blood
Hypertension, Pulmonary - etiology
Lung diseases
Male
Prognosis
Proteins
Pulmonary Artery - physiopathology
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - complications
Respiratory tract diseases
Smoking
Sputum
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Summary:Chronic Obstructive Pulmonary Disease (COPD), which is caused by various proinflammatory cytokines, will present some kinds of complication with progression such as Pulmonary Artery Hypertension (PAH). CRP (C-Reactive Protein) and ET-1(Endotheline-1) play pivotal function in inflammatory responses. The aim of this study is to investigate the prognosis value of CRP and ET-1 in COPD patients with pulmonary artery hypertension. CRP and ET-1 were measured in the plasma, sputum and exhaled breath condensate (EBC) of 55 COPD patients, 75 COPD patients with PAH and 57 healthy controls. Then, we analyzed the influence of these two proteins on the lung function, pulmonary artery pressure, exercise capacity and other clinical indices. The amount of CRP and ET-1 were the highest in COPD patients with PAH, followed by the COPD patients and the healthy controls. And there were statistically significant differences (p
ISSN:1011-601X