Superinfective Hepatitis E Virus Infection Aggravates Hepatocytes Injury in Chronic Hepatitis B

Summary Hepatitis E virus (HEV) infection is a major cause of morbidity in endemic areas. Its consequences among chronic hepatitis B (CHB) patients have been under-reported. The aim of this study was to assess the impact of superinfective HEV infection (acute and past) on virological and clinical fe...

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Bibliographic Details
Published in:Current medical science 2019-10, Vol.39 (5), p.719-726
Main Authors: Kilonzo, Semvua Bukheti, Wang, Yong-li, Jiang, Qun-qun, Wu, Wen-yu, Wang, Peng, Ning, Qin, Han, Mei-fang
Format: Article
Language:English
Subjects:
Acute-On-Chronic Liver Failure - complications
Acute-On-Chronic Liver Failure - immunology
Acute-On-Chronic Liver Failure - pathology
Acute-On-Chronic Liver Failure - virology
Adult
Aged
Alanine Transaminase - blood
Alanine Transaminase - immunology
Ascites - complications
Ascites - immunology
Ascites - pathology
Ascites - virology
Bilirubin - blood
Bilirubin - immunology
China
Female
Hepatic Encephalopathy - complications
Hepatic Encephalopathy - immunology
Hepatic Encephalopathy - pathology
Hepatic Encephalopathy - virology
Hepatitis Antibodies - blood
Hepatitis B virus - immunology
Hepatitis B virus - pathogenicity
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - virology
Hepatitis E - complications
Hepatitis E - immunology
Hepatitis E - pathology
Hepatitis E - virology
Hepatitis E virus - immunology
Hepatitis E virus - pathogenicity
Hepatocytes - immunology
Hepatocytes - pathology
Hepatocytes - virology
Hepatorenal Syndrome - complications
Hepatorenal Syndrome - immunology
Hepatorenal Syndrome - pathology
Hepatorenal Syndrome - virology
Humans
Immunoglobulin G - blood
Interleukin-10 - blood
Interleukin-10 - immunology
Interleukin-6 - blood
Interleukin-6 - immunology
Liver - immunology
Liver - pathology
Liver - virology
Liver Cirrhosis - complications
Liver Cirrhosis - immunology
Liver Cirrhosis - pathology
Liver Cirrhosis - virology
Male
Medicine
Medicine & Public Health
Middle Aged
Retrospective Studies
Superinfection - complications
Superinfection - immunology
Superinfection - pathology
Superinfection - virology
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - immunology
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Summary:Summary Hepatitis E virus (HEV) infection is a major cause of morbidity in endemic areas. Its consequences among chronic hepatitis B (CHB) patients have been under-reported. The aim of this study was to assess the impact of superinfective HEV infection (acute and past) on virological and clinical features of patients with CHB infection. Clinical, biochemical, virological and immunological data of 153 CHB patients including 98 with hepatitis B virus (HBV) monoinfection and 55 with HBV-HEV superinfection with both HEV and HBV infection was retrospectively investigated and analyzed in this study conducted in Wuhan, China. An overall anti-HEV IgG seroprevalence was found to be 35.9% in CHB patients. HBV-HEV superinfection patients showed significantly higher rate of complications (ascites, hepato-renal syndrome & encephalopathy) (all with P =0.04), cirrhosis ( P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-019-2097-0